The effect of tumor volume and its change on survival in stage III non-small cell lung cancer treated with definitive concurrent chemoradiotherapy.
The effect of tumor volume and its change on survival in stage III non-small cell lung cancer treated with definitive concurrent chemoradiotherapy.
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DOI：
10.1186/s13014-014-0283-6
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发表时间：
2014-12-13
期刊：
影响因子：
--
通讯作者：
Lee JS
中科院分区：
文献类型：
--
作者：
Koo TR;Moon SH;Lim YJ;Kim JY;Kim Y;Kim TH;Cho KH;Han JY;Lee YJ;Yun T;Kim HT;Lee JS
目的探讨大体肿瘤体积(GTV)变化对III期非小细胞肺癌(NSCLC)同期放化疗(CCRT)患者预后的影响。从2001年到2009年，我们招募了191名接受CCRT的III期非小细胞肺癌患者。157例患者在CCRT前进行计划CT扫描，并在CCRT后1个月复查CT。测定治疗前GTV(GTVPre)、治疗后GTV(GTVpost)的体积参数和GTV的体积缩小率(VRR)。主要终点是总生存期(OS)，次要终点是无进展生存期(PFS)和局部无进展生存期(LRPFS)。最佳截断值定义为两组间差异最大的截断值。存活患者的中位随访期为52.7个月。中位生存期、3年OS、PFS和LRPFS率分别为25.5个月、36.4%、23.0%和45.0%。选定的截止值为GTVpre为50%，GTVpost为20%，VRR为50%。单因素分析显示，较小的GTVpre和GTVpost值分别与较好的OS(p <； 0.001和p = 0.015)和PFS(p = 0.001和p = 0.004)相关。 >； 50%的VRR较高与OS(p = 0.004)和PFS(p = 0.054)较差的趋势相关。经多因素分析，较小的GTVPre表明OS(p = 0.001)、PFS(p = 0.013)和LRPFS(p = 0.002)显著改善，而GTVpost较小的GTVpost对PFS影响不显著(p = 0.086)。较高的VRR与操作系统较差的趋势相关(p = 0.075)。在接受CCRT的III期NSCLC患者中，GTVpre是一个独立的预后因素。值得注意的是，仅用CT进行短期随访后，改善的结果与较高的VRR无关。本文的在线版本(doi：10.1186/s130140140283-6)包含补充材料，授权用户可以使用。
To investigate a prognostic role of gross tumor volume (GTV) changes on survival outcomes following concurrent chemoradiotherapy (CCRT) in stage III non-small-cell lung cancer (NSCLC) patients. We enrolled 191 patients with stage III NSCLC from 2001 to 2009 undergoing definitive CCRT. The GTV of 157 patients was delineated at the planning CT prior to CCRT and with a follow-up CT 1 month after CCRT. We assessed the volumetric parameters of pre-treatment GTV (GTVpre) post-treatment GTV (GTVpost), and volume reduction ratio of GTV (VRR). The primary endpoint was overall survival (OS) and secondary endpoints were progression-free survival (PFS) and locoregional progression-free survival (LRPFS). The best cut-off value was defined as that which exhibited the maximum difference between the two groups. The median follow-up duration was 52.7 months in surviving patients. Median survival, 3-year OS, PFS and LRPFS rates were 25.5 months, 36.4%, 23.0%, and 45.0%, respectively. The selected cut-off values were 50 cm3 for GTVpre, 20 cm3 for GTVpost, and 50% for VRR. The smaller GTVpre and GTVpost values were associated with better OS (p < 0.001 and p = 0.015) and PFS (p = 0.001 and p = 0.004), respectively, upon univariate analysis. The higher VRR of > 50% was associated with a trend toward poorer OS (p = 0.004) and PFS (p = 0.054). Upon multivariate analysis, smaller GTVpre indicated significantly improved OS (p = 0.001), PFS (p = 0.013) and LRPFS (p = 0.002), while smaller GTVpost was marginally significant for PFS (p = 0.086). Higher VRR was associated with a trend toward poorer OS (p = 0.075). In patients with stage III NSCLC undergoing definitive CCRT, GTVpre was an independent prognostic factor of survival. Notably, improved outcome was not correlated with higher VRR after short-term follow-up with CT alone. The online version of this article (doi:10.1186/s13014-014-0283-6) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/s0360-3016(02)02814-6
发表时间：
2002-07-15
影响因子：
7
作者：
Etiz, D;Marks, LB;Lind, PA
通讯作者：
Lind, PA
影响因子：
45.3
作者：
Scagliotti, Giorgio V.;Pastorino, Ugo;Torri, Valter
通讯作者：
Torri, Valter
影响因子：
3.4
作者：
Pourel, Nicolas;Santelmo, Nicola;Reboul, Francois
通讯作者：
Reboul, Francois
影响因子：
3.6
作者：
Lee P;Bazan JG;Lavori PW;Weerasuriya DK;Quon A;Le QT;Wakelee HA;Graves EE;Loo BW
通讯作者：
Loo BW
影响因子：
45.3
作者：
Mac Manus, MP;Hicks, RJ;Ball, DL
通讯作者：
Ball, DL