The Healthy Brains and Behavior Study: objectives, design, recruitment, and population coverage.
The Healthy Brains and Behavior Study: objectives, design, recruitment, and population coverage.
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DOI：
10.1002/mpr.1394
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发表时间：
2013-09
影响因子：
3.1
通讯作者：
Gur RE
中科院分区：
文献类型：
--
作者：
Liu J;Richmond TS;Raine A;Cheney R;Brodkin ES;Gur RC;Gur RE
暴力越来越被视为一个公共卫生问题，可以通过基于健康的干预措施加以改善。健康大脑和行为研究（HBBS）旨在确定儿童后期攻击的环境和生物风险因素，并通过心理和营养治疗减少攻击。利用跨学科的合作研究方法，HBBS具有人类和动物成分。人的部分有两个阶段，包括风险评估和治疗。风险评估基于451名11-12岁的社区居住儿童及其照顾者，在此期间收集了遗传、脑成像、神经内分泌、心理生理学、环境毒理学、神经认知、营养、心理、社会和人口统计学风险变量。符合攻击行为标准的儿童（N = 219）被分配到四个治疗组之一：单独的认知行为治疗（CBT），单独的营养补充剂，CBT和营养，或照常治疗。治疗持续时间为12周，所有儿童无论是否接受治疗，均在3个月、6个月和12个月进行随访。动物部分评估了饮食ω-3脂肪酸对攻击性发展的影响。这项研究有助于了解生物因素如何与社会因素相互作用，形成主动和被动的侵略，并评估治疗方法的有效性，以减少儿童的侵略。
Violence is increasingly viewed as a public health issue that may be ameliorated by health-based interventions. The Healthy Brains and Behavior Study (HBBS) aims to identify environmental and biological risk factors for aggression in late childhood and to reduce aggression through psychological and nutritional treatments. Utilizing a cross-disciplinary collaborative research approach, the HBBS has both human and animal components. The human component has two stages consisting of risk assessment followed by treatment. The risk assessment is based on 451 community-residing children aged 11–12 years and their caregivers, during which genetic, brain imaging, neuroendocrine, psychophysiology, environment toxicology, neurocognitive, nutrition, psychological, social and demographic risk variables are collected. Children who met criteria (N = 219) for problematic aggressive behaviors were assigned to one of four treatment groups: cognitive-behavior therapy (CBT) alone, nutritional supplements alone, both CBT and nutrition, or treatment-as-usual. Treatment duration was 12 weeks and all children whether in treatment or not were followed-up at three, six, and 12 months. The animal component assessed the effects of dietary omega-3 fatty acids on the development of aggression. This study contributes knowledge on how biological factors interact with social factors in shaping proactive and reactive aggression and assesses the efficacy of treatment approaches to reduce childhood aggression.
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