Macular assessment using optical coherence tomography for glaucoma diagnosis.
Macular assessment using optical coherence tomography for glaucoma diagnosis.
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DOI：
10.1136/bjophthalmol-2012-301845
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Schuman JS
中科院分区：
文献类型：
--
作者：
Sung KR;Wollstein G;Kim NR;Na JH;Nevins JE;Kim CY;Schuman JS
光学相干断层扫描（OCT）是一种基于干涉的成像模式，可生成视网膜的高分辨率横截面图像。视乳头周围视网膜神经纤维层（cpRNFL）和视神经乳头的评估是OCT的主要结构测量。然而，由于这些测量并不总是可用或精确的，这将是有用的，有另一个可靠的指标。黄斑已被建议作为青光眼诊断的替代扫描位置。使用时域（TD-）OCT，黄斑测量已经显示出提供良好的青光眼诊断能力。随着采用光谱域OCT，它允许比TD-OCT更高的图像分辨率，内部黄斑层的分割成为可能。这些层特别容易发生昏迷性损伤，并且厚度测量显示出与昏迷性cpRNFL测量相当的性能。黄斑测量在青光眼进展检测中的作用仍在研究中。更复杂的测量和分析工具，可以放大黄斑测量的优势，预计。例如，图像质量的改善将允许更好的可视化，各种扫描模式的开发将优化黄斑测量，并且分析算法的进一步改进将提供更准确的分割。有了这些成就，黄斑测量可以成为一个重要的替代青光眼结构评估。
Optical coherence tomography (OCT) is an interferometry-based imaging modality that generates high-resolution cross-sectional images of the retina. Circumpapillary retinal nerve fiber layer (cpRNFL) and optic nerve head assessments are the mainstay of glaucomatous structural measurements in OCT. However, because these measurements are not always available or precise, it would be useful to have another reliable indicator. The macula has been suggested as an alternative scanning location for glaucoma diagnosis. Using time-domain (TD-) OCT, macular measurements have shown to provide good glaucoma diagnostic capabilities. With the adoption of spectral-domain OCT, which allows a higher image resolution than TD-OCT, segmentation of inner macular layers becomes possible. These layers are specifically prone to glaucomatous damage and thickness measurements show a comparable performance to that of glaucomatous cpRNFL measurements. The role of macular measurements for detection of glaucoma progression is still under investigation. More sophisticated measurement and analysis tools that can amplify the advantages of macular measurements are expected. For example, improvement of image quality would allow better visualization, development of various scanning modes would optimize macular measurements, and further refining of the analytical algorithm would provide more accurate segmentation. With these achievements, macular measurement can be an important surrogate for glaucomatous structural assessment.
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