Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice.
Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice.
复制标题
人牙纸浆干细胞移植对链蛋白酶诱导的1型糖尿病模型小鼠糖尿病多神经病的可持续作用。
DOI：
10.3390/cells10092473
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发表时间：
2021-09-18
期刊：
影响因子：
6
通讯作者：
Naruse K
中科院分区：
文献类型：
--
作者：
Hata M;Omi M;Kobayashi Y;Nakamura N;Miyabe M;Ito M;Ohno T;Imanishi Y;Himeno T;Kamiya H;Nakamura J;Miyachi H;Ozawa S;Miyazawa K;Mitani A;Nagao T;Goto S;Takebe J;Matsubara T;Naruse K
牙髓干细胞（DPSC）适用于再生医学。冻存人DPSC（hDPSC）可改善糖尿病多发性神经病变，其作用与VEGF和NGF分泌有关。本研究评估了hDPSC单次移植对糖尿病多发性神经病的长期影响。从正畸治疗中拔除的人第三磨牙中获得hDPSCs，然后将其移植到链脲佐菌素注射后8周的裸鼠单侧后肢骨骼肌中。在移植后16周分析hDPSC移植的效果。DPSC移植显著改善延迟神经传导速度，减少血流量，并增加感觉阈值。此外，hDPSC条件培养基促进背根神经节神经元突起的生长。总之，单次注射hDPSC移植的治疗效果持续很长时间，并且可能有益于治疗长期糖尿病多发性神经病。
Dental pulp stem cells (DPSCs) are suitable for use in regenerative medicine. Cryopreserved human DPSCs (hDPSCs) ameliorate diabetic polyneuropathy, and the effects of hDPSC transplantation are related to VEGF and NGF secretion. This study evaluated the long-term effects of a single transplantation of hDPSCs on diabetic polyneuropathy. hDPSCs were obtained from human third molars extracted for orthodontic treatment, which were then transplanted into the unilateral hindlimb skeletal muscles 8 weeks after streptozotocin injection in nude mice. The effects of hDPSC transplantation were analyzed at 16 weeks post-transplantation. DPSC transplantation significantly improved delayed nerve conduction velocity, decreased blood flow, and increased sensory perception thresholds. Furthermore, the hDPSC-conditioned medium promoted the neurite outgrowth of dorsal root ganglion neurons. In conclusion, the therapeutic effects of hDPSC transplantation with a single injection last for prolonged periods and may be beneficial in treating long-term diabetic polyneuropathy.
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影响因子：
5.6
作者：
Kanada S;Makino E;Nakamura N;Miyabe M;Ito M;Hata M;Yamauchi T;Sawada N;Kondo S;Saiki T;Minato T;Miyazawa K;Goto S;Matsubara T;Naruse K
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Naruse K
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5.2
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16.2
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3.3
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通讯作者：
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影响因子：
7.5
作者：
Hata, Masaki;Omi, Maiko;Naruse, Keiko
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