SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters.
SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters.
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与叙利亚仓鼠的富米特暴露相比，空中疾病的SARS-COV-2疾病严重程度和传播效率提高了。
DOI：
10.1038/s41467-021-25156-8
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发表时间：
2021-08-17
影响因子：
16.6
通讯作者：
Munster VJ
中科院分区：
文献类型：
--
作者：
Port JR;Yinda CK;Owusu IO;Holbrook M;Fischer R;Bushmaker T;Avanzato VA;Schulz JE;Martens C;van Doremalen N;Clancy CS;Munster VJ
SARS-CoV-2的传播由接触传播、污染物传播和空气传播驱动。不同传播途径的相对贡献仍然存在争议。在这里，我们显示叙利亚仓鼠容易通过鼻内、气溶胶和污染物暴露感染SARS-CoV-2。不同的接触途径有不同的疾病表现。鼻内和气雾剂接种可引起严重的呼吸道病理、更高的病毒载量和体重减轻。相比之下，暴露于污染物会导致较轻的疾病表现，其特征是抗炎免疫状态和延迟脱落模式。尽管呼吸道病毒脱落的总体程度与疾病的严重程度无关，但脱落的开始与疾病的严重程度有关。早期脱落与疾病严重程度的增加有关。空气传播比空气传播更有效，并且取决于气流的方向。仔细表征SARS-CoV-2传播模型对于评估正在进行的SARS-CoV-2进化中传播和致病潜力的潜在变化至关重要。在这里，Port和Yinda等人直接比较了SARS-CoV-2的接触、污染物和空气传播途径对叙利亚仓鼠疾病结局的相对贡献；虽然鼻内和气溶胶接种可引起严重的发病机制，但接触污染物的特点是病情较轻。
Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject to debate. Here, we show Syrian hamsters are susceptible to SARS-CoV-2 infection through intranasal, aerosol and fomite exposure. Different routes of exposure present with distinct disease manifestations. Intranasal and aerosol inoculation causes severe respiratory pathology, higher virus loads and increased weight loss. In contrast, fomite exposure leads to milder disease manifestation characterized by an anti-inflammatory immune state and delayed shedding pattern. Whereas the overall magnitude of respiratory virus shedding is not linked to disease severity, the onset of shedding is. Early shedding is linked to an increase in disease severity. Airborne transmission is more efficient than fomite transmission and dependent on the direction of the airflow. Carefully characterized SARS-CoV-2 transmission models will be crucial to assess potential changes in transmission and pathogenic potential in the light of the ongoing SARS-CoV-2 evolution. Here, Port and Yinda et al. directly compare the relative contribution of contact, fomite, and airborne transmission route of SARS-CoV-2 to disease outcome in Syrian hamsters; while intranasal and aerosol inoculation causes severe pathogenesis, fomite exposure is characterized by milder disease.
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影响因子：
3.8
作者：
Hammoud DA;Lentz MR;Lara A;Bohannon JK;Feuerstein I;Huzella L;Jahrling PB;Lackemeyer M;Laux J;Rojas O;Sayre P;Solomon J;Cong Y;Munster V;Holbrook MR
通讯作者：
Holbrook MR
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
DOI：
10.1126/science.abe8499
发表时间：
2020-12-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hou YJ;Chiba S;Halfmann P;Ehre C;Kuroda M;Dinnon KH 3rd;Leist SR;Schäfer A;Nakajima N;Takahashi K;Lee RE;Mascenik TM;Graham R;Edwards CE;Tse LV;Okuda K;Markmann AJ;Bartelt L;de Silva A;Margolis DM;Boucher RC;Randell SH;Suzuki T;Gralinski LE;Kawaoka Y;Baric RS
通讯作者：
Baric RS
DOI：
10.1016/j.vascn.2003.07.001
发表时间：
2004-01-01
影响因子：
1.9
作者：
Hartings, Justin M.;Roy, Chad J.
通讯作者：
Roy, Chad J.
影响因子：
24.3
作者：
Guan, Wei-jie;Liang, Wen-hua;He, Jian-xing
通讯作者：
He, Jian-xing