Ethanol effects on embryonic craniofacial growth and development: implications for study of the fetal alcohol syndrome.
Ethanol effects on embryonic craniofacial growth and development: implications for study of the fetal alcohol syndrome.
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乙醇对胚胎颅面生长和发育的影响：对胎儿酒精综合征研究的影响。
DOI：
10.1111/j.1530-0277.1994.tb00900.x
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Pisano,MM
中科院分区：
文献类型：
--
作者：
Weston,WM;Greene,RM;Uberti,M;Pisano,MM
Fetal alcohol syndrome (FAS), which is brought about by maternal consumption of ethanol during pregnancy, is a major public health problem. To gain understanding of the etiology of this condition, a number of teratological studies have been performed in different animal systems to develop an animal model for FAS. The C57BL/6J mouse strain has been described as susceptible to the teratogenic effects of ethanol, whereas the ICR (CD‐1) strain is considered relatively insensitive. We have compared the effects of ethanol on DNA and protein synthesis in cultured embryonic palate mesenchymal cells from both strains to determine if the reported differential sensitivity to ethanol is reflected in differences in ethanol's effects on cell behavior. Chronic exposure to 200 mM ethanol for 48 hr had a strong inhibitory effect on DNA synthesis in palate cells derived from both the C57BL/6J and ICR strains and a significant effect on protein synthesis in C57BL/6J palate cells. When we attempted to verify strain differences in susceptibility to ethanol teratogenesis, we were not able to observe an increased incidence of birth defects due to ethanol in either strain. High doses of ethanol (5.8 g/kg, administered by intraperitoneal injection on gestational day 8) resulted in death in both C57BL/6J and ICR mice. A lower dose (4.8 g/kg) caused decreased fetal weight and increased resorption in both strains, but did not bring about FAS‐like craniofacial dysmorphology in either strain. It appears, therefore, that whereas ethanol can significantly affect the behavior of cells derived from craniofacial tissue, these effects cannot be correlated with sensitivity to ethanol teratogenesis in the mouse system. In view of these results, we suggest that the suitability of the mouse model for FAS be reviewed.
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两种近交系小鼠单次接触后酒精对产前的影响。
DOI：
--
发表时间：
1992
期刊：
Annals of Anatomy
影响因子：
--
作者：
T. Persaud;G. Sam
通讯作者：
G. Sam
乙醇对小鼠的致畸性：光学显微镜研究。
DOI：
10.1002/tera.1420260305
发表时间：
1982
期刊：
Teratology
影响因子：
--
作者：
J. Bannigan;P. Burke
通讯作者：
P. Burke
乙醇对蛋白质合成的影响。
影响因子：
--
作者：
M. Rothschild;S. Schreiber;M. Oratz
通讯作者：
M. Oratz
乙醇对小鼠胚胎腭间充质细胞 cAMP 产生的影响。
影响因子：
6.1
作者：
Weston,WM;Greene,RM
通讯作者：
Greene,RM
DOI：
10.1002/tera.1420220110
发表时间：
1980-01-01
期刊：
TERATOLOGY
影响因子：
--
作者：
CHERNOFF, GF
通讯作者：
CHERNOFF, GF