Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.
Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses.
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DOI：
10.3390/ijms19030694
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发表时间：
2018-02-28
影响因子：
5.6
通讯作者：
González-Sarrías A
中科院分区：
文献类型：
--
作者：
García-Conesa MT;Chambers K;Combet E;Pinto P;Garcia-Aloy M;Andrés-Lacueva C;de Pascual-Teresa S;Mena P;Konic Ristic A;Hollands WJ;Kroon PA;Rodríguez-Mateos A;Istas G;Kontogiorgis CA;Rai DK;Gibney ER;Morand C;Espín JC;González-Sarrías A
了解个体间的差异，以响应膳食多酚仍然是必不可少的，以阐明其对心脏代谢疾病的发展的影响。对128项随机临床试验进行了荟萃分析，以研究浆果和红葡萄/葡萄酒作为花青素来源以及坚果和石榴作为鞣花单宁来源对一系列心脏代谢风险生物标志物的影响。探讨了各种人口统计学和生活方式因素对这些产品反应变异性的潜在影响。含花青素和鞣花单宁的产品都能降低总胆固醇，坚果和浆果比石榴和葡萄的效果更显著。血压显着降低的两个主要来源的花青素，浆果和红葡萄/葡萄酒，而腰围，低密度脂蛋白胆固醇，甘油三酯和葡萄糖是最显着降低的鞣花单宁产品，特别是坚果。此外，我们发现了一个迹象表明，高密度脂蛋白胆固醇的增加最显着的坚果，并在流量介导的扩张坚果和浆果。大多数这些影响在肥胖/超重人群中检测到，但我们在体重正常的人群中发现了有限或无证据，或者发现了性别或吸烟状态的影响。其他因素的影响，即，习惯性饮食、健康状况或进行研究的国家不一致，需要进一步调查。
Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.
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DOI：
10.1016/j.nutres.2010.06.016
发表时间：
2010-07
期刊：
Nutrition research (New York, N.Y.)
影响因子：
--
作者：
Basu A;Fu DX;Wilkinson M;Simmons B;Wu M;Betts NM;Du M;Lyons TJ
通讯作者：
Lyons TJ
DOI：
10.1080/07315724.2010.10719816
发表时间：
2010-02-01
影响因子：
3.5
作者：
Burton-Freeman, Britt;Linares, Amanda;Kappagoda, Tissa
通讯作者：
Kappagoda, Tissa
影响因子：
7.1
作者：
Cassidy, Aedin;O'Reilly, Eilis J.;Rimm, Eric B.
通讯作者：
Rimm, Eric B.
影响因子：
4.7
作者：
Cerdá, B;Soto, C;Espín, JC
通讯作者：
Espín, JC
影响因子：
1.6
作者：
Asgary, Sedigheh;Kelishadi, Roya;Sahebkar, Amirhossein
通讯作者：
Sahebkar, Amirhossein