Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages.
Effects of short-term administration of estradiol on reperfusion arrhythmias in rats of different ages.
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DOI：
10.1590/s0100-879x2012007500169
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Almeida AP
中科院分区：
文献类型：
--
作者：
Savergnini SQ;Reis AM;Santos RA;Santos PE;Ferreira AJ;Almeida AP
雌激素对缺血再灌注(I/R)损伤的短期效应与年龄相关的差异知之甚少。本研究旨在观察雌二醇短期给药对6~7周龄和12~14月龄雌性大鼠心脏再灌注性心律失常的影响。将Wistar大鼠分为假手术组、去卵巢组和去卵巢+17β-雌二醇组(雌二醇组：5 µg·100 g−1·day−1)，共4d。心脏通过兰登多夫技术进行灌流。结扎左冠状动脉15 ，再灌流30 ，诱发再灌注性心律失常，即室性心动过速和/或室颤。青年大鼠I/R持续时间和发生率显著高于中年大鼠(心律失常严重指数：9.4±1.0vs3.0±0.3，P<；0.05)。此外，中年大鼠表现出较低的心率、收缩压和冠脉流量。四天的E2治疗导致子宫重量增加。E_2对中年大鼠I/R心律失常持续时间无明显影响，但能显著减少幼年大鼠的节律紊乱，并伴有离体心的心率减慢。此外，这种减少与QT间期的增加有关。中年雌二醇组大鼠QT间期无明显变化。这些数据表明，短期雌激素治疗对幼年雌性大鼠心脏的I/R心律失常具有保护作用。雌二醇的抗心律失常作用可能与延长QT间期有关。
Little is known about age-related differences in short-term effects of estradiol on ischemia-reperfusion (I/R) insults. The present study was designed to evaluate the effects of short-term treatment with estradiol on reperfusion arrhythmias in isolated hearts of 6-7-week-old and 12-14-month-old female rats. Wistar rats were sham-operated, ovariectomized and treated with vehicle or ovariectomized and treated with 17β-estradiol (E2; 5 µg·100 g−1·day−1) for 4 days. Hearts were perfused by the Langendorff technique. Reperfusion arrhythmias, i.e., ventricular tachycardia and/or ventricular fibrillation, were induced by 15 min of left coronary artery ligation and 30 min of reperfusion. The duration and incidence of I/R arrhythmias were significantly higher in young rats compared to middle-aged rats (arrhythmia severity index: 9.4 ± 1.0 vs 3.0 ± 0.3 arbitrary units, respectively, P < 0.05). In addition, middle-aged rats showed lower heart rate, systolic tension and coronary flow. Four-day E2 treatment caused an increase in uterine weight. Although E2 administration had no significant effect on the duration of I/R arrhythmias in middle-aged rats, it induced a marked reduction in the rhythm disturbances of young rats accompanied by a decrease in heart rate of isolated hearts. Also, this reduction was associated with an increase in QT interval. No significant changes were observed in the QT interval of middle-aged E2-treated rats. These data demonstrate that short-term estradiol treatment protects against I/R arrhythmias in hearts of young female rats. The anti-arrhythmogenic effect of estradiol might be related to a lengthening of the QT interval.
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影响因子：
64.8
作者：
LANG, RE;THOLKEN, H;UNGER, T
通讯作者：
UNGER, T
影响因子：
2.8
作者：
Burke, JH;Ehlert, FA;Kadish, AH
通讯作者：
Kadish, AH
影响因子：
--
作者：
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通讯作者：
Bland, KI
影响因子：
5.5
作者：
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通讯作者：
Gaznabi, AKM
影响因子：
9.3
作者：
Li, Jun;Xiao, Junjie;Chen, Yi-Han
通讯作者：
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