Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity.
Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity.
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DOI：
10.1111/cmi.12388
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发表时间：
2015-04
影响因子：
3.4
通讯作者：
Brown GD
中科院分区：
文献类型：
--
作者：
Vautier S;Drummond RA;Chen K;Murray GI;Kadosh D;Brown AJ;Gow NA;MacCallum DM;Kolls JK;Brown GD
白色念珠菌引起疾病的能力与其在酵母和丝状形式之间进行形态转变的能力有关，但形态在胃肠道 (GI) 定植和传播中的作用仍不清楚。为了探索这一点，我们在已建立的胃肠道定植模型中使用了白色念珠菌的野生型和形态突变体，该模型是在对小鼠进行抗生素治疗后诱导的。我们的数据表明，胃肠道定植有利于白色念珠菌的酵母形式，定植小鼠中存在组成性低水平的全身性传播，无论真菌形态如何，并且在其他免疫功能正常的动物中，定植不受 Th17 免疫控制。这些数据为白色念珠菌的发病机制和共生机制提供了新的见解，并对我们对人类疾病的理解具有重要意义。
The ability of Candida albicans to cause disease is associated with its capacity to undergo morphological transition between yeast and filamentous forms, but the role of morphology in colonization and dissemination from the gastrointestinal (GI) tract remains poorly defined. To explore this, we made use of wild-type and morphological mutants of C. albicans in an established model of GI tract colonization, induced following antibiotic treatment of mice. Our data reveal that GI tract colonization favours the yeast form of C. albicans, that there is constitutive low level systemic dissemination in colonized mice that occurs irrespective of fungal morphology, and that colonization is not controlled by Th17 immunity in otherwise immunocompetent animals. These data provide new insights into the mechanisms of pathogenesis and commensalism of C. albicans, and have implications for our understanding of human disease.
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影响因子：
9.8
作者：
Rochereau N;Drocourt D;Perouzel E;Pavot V;Redelinghuys P;Brown GD;Tiraby G;Roblin X;Verrier B;Genin C;Corthésy B;Paul S
通讯作者：
Paul S
影响因子：
3.7
作者：
Sgroi A;Gonelle-Gispert C;Morel P;Baertschiger RM;Niclauss N;Mentha G;Majno P;Serre-Beinier V;Buhler L
通讯作者：
Buhler L
影响因子：
6.4
作者：
OWEN, RL;PIERCE, NF;CRAY, WC
通讯作者：
CRAY, WC
影响因子：
64.5
作者：
Lo, HJ;Kohler, JR;Fink, GR
通讯作者：
Fink, GR
影响因子：
30.3
作者：
Meinzer, Ulrich;Barreau, Frederick;Hugot, Jean-Pierre
通讯作者：
Hugot, Jean-Pierre