Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics.
Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics.
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DOI：
10.1038/s41370-022-00451-8
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发表时间：
2022-11
影响因子：
4.5
通讯作者：
Rager, Julia E.
中科院分区：
文献类型：
--
作者：
Koval, Lauren E.;Dionisio, Kathie L.;Friedman, Katie Paul;Isaacs, Kristin K.;Rager, Julia E.
虽然将环境化学品与乳腺癌联系起来的证据越来越多，但缺乏基于混合物的暴露评估。本研究旨在确定与乳腺癌相关的化学品共存和共享特性的环境化学品库存，突出可能改变疾病风险的暴露组合。使用化学品和产品数据库对化学品使用类别中的化学品的出现情况进行了描述。通过查询寂静的春天研究所的乳腺癌审查数据库和美国环境保护署的毒性参考数据库，对与乳腺癌（BC）、未知关联（NBC）和研究不足的化学品（UC）有关联的化学品的共同暴露模式进行了评估。根据结构和物理化学相似性以及与环境相关暴露源中的BC共存模式对UC进行排名。共有6，793种化学品有数据可用于接触源发生率分析。根据与共现BC的共同特性，包括用于食品生产和消费者/个人护理产品的化学品以及潜在的内分泌系统调节剂，对跨越五组共现化学品的50个顶级UC进行了优先排序。结果强调了在我们的日常环境中可能普遍存在的重要的共同暴露条件，这些条件需要进一步评估可能的乳腺癌风险。
Although evidence linking environmental chemicals to breast cancer is growing, mixtures-based exposure evaluations are lacking. This study aimed to identify environmental chemicals in use inventories that co-occur and share properties with chemicals that have association with breast cancer, highlighting exposure combinations that may alter disease risk. The occurrence of chemicals within chemical use categories was characterized using the Chemical and Products Database. Co-exposure patterns were evaluated for chemicals that have an association with breast cancer (BC), no known association (NBC), and understudied chemicals (UC) identified through query of the Silent Spring Institute’s Mammary Carcinogens Review Database and the U.S. Environmental Protection Agency’s Toxicity Reference Database. UCs were ranked based on structure and physicochemical similarities and co-occurrence patterns with BCs within environmentally relevant exposure sources. A total of 6,793 chemicals had data available for exposure source occurrence analyses. 50 top-ranking UCs spanning five clusters of co-occurring chemicals were prioritized, based on shared properties with co-occuring BCs, including chemicals used in food production and consumer/personal care products, as well as potential endocrine system modulators. Results highlight important co-exposure conditions that are likely prevalent within our everyday environments that warrant further evaluation for possible breast cancer risk.
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影响因子：
10.4
作者：
Auerbach S;Filer D;Reif D;Walker V;Holloway AC;Schlezinger J;Srinivasan S;Svoboda D;Judson R;Bucher JR;Thayer KA
通讯作者：
Thayer KA
DOI：
10.1186/s12940-017-0287-4
发表时间：
2017-09-02
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Gray JM;Rasanayagam S;Engel C;Rizzo J
通讯作者：
Rizzo J
影响因子：
9.8
作者：
Dionisio KL;Phillips K;Price PS;Grulke CM;Williams A;Biryol D;Hong T;Isaacs KK
通讯作者：
Isaacs KK
影响因子：
--
作者：
Apostolou P;Fostira F
通讯作者：
Fostira F
影响因子：
2.4
作者：
Harvey, J. B.;Hong, H. -H. L.;Hoenerhoff, M. J.
通讯作者：
Hoenerhoff, M. J.