Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomization analysis
Overall and central obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomization analysis
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中国汉族人群总体肥胖和向心性肥胖与胰岛素敏感性和分泌的关系：孟德尔随机分析
DOI：
10.1038/ijo.2016.155
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发表时间：
2016-08
影响因子：
4.9
通讯作者：
Jia W
中科院分区：
文献类型：
--
作者：
Wang T;Ma X;Tang T;Jin L;Peng D;Zhang R;Chen M;Yan J;Wang S;Yan D;He Z;Jiang F;Cheng X;Bao Y;Liu Z;Hu C;Jia W
结果：BMI和WHR均与胰岛素分泌和胰岛素敏感指数呈正相关。MR分析显示，遗传决定的体重指数增加1SD(3.35kgm−2)，导致单位为178.18 pmoL L−1增加第一时相胰岛素分泌单位和35.52pmoL L−1单位第二时相胰岛素分泌单位(分别为P=0.001和0.002)，且与中心性肥胖无关(分别为P=0.019和0.039)。相比之下，遗传决定的高1SD腰围比(腰围比变化0.002)导致胰岛素抵抗的稳态模型评估增加1.21U，Gutt指数(代表胰岛素敏感性)降低18.40%(分别为P=0.048和0.028)。在观察到的关联和遗传估计关联之间不存在实质性的异质性(P代表差异>；0.05)。结论：我们提供了新的因果证据，表明在中国汉族人群中，肥胖对胰岛素分泌和敏感性的影响可能在总体肥胖和中心性肥胖之间有所不同，并确定了总体肥胖对代偿性胰岛素分泌的影响程度，以及中心性肥胖与胰岛素敏感性的负相关。
Results:Both of BMI and WHR were observationally correlated with insulin secretion and sensitivity indices. The MR analysis demonstrated that a genetically determined 1 sd (3.35 kg m− 2) higher BMI caused a unit of 178.18 pmol l− 1 higher Stumvoll first-phase and 35.52 pmol l− 1 higher Stumvoll second-phase insulin secretion (P= 0.001 and 0.002, respectively), which were even independent of central obesity (P= 0.019 and 0.039, respectively). In contrast, a genetically determined 1 sd higher WHR (a change of 0.002 in WHR) caused a unit of 1.21 higher homeostasis model assessment of insulin resistance and 18.40 lower Gutt index (representing the insulin sensitivity)(P= 0.048 and 0.028, respectively). No substantial heterogeneity existed between the observed associations and the genetic estimated associations (P for difference> 0.05).Conclusions:We provide new causal evidence that the impact of obesity on insulin secretion and sensitivity could vary between overall obesity and central obesity in Han Chinese populations and also identify the extent to which overall obesity affects compensatory insulin secretion and central obesity inversely links to insulin sensitivity.
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DOI：
10.1097/01.hcr.0000348169.97212.87
发表时间：
2009-03
影响因子：
3.8
作者：
B. Carlin;J. Roitman
通讯作者：
B. Carlin;J. Roitman
影响因子：
2
作者：
M. Takahara;N. Katakami;H. Kaneto;Midori Noguchi;I. Shimomura
通讯作者：
M. Takahara;N. Katakami;H. Kaneto;Midori Noguchi;I. Shimomura
DOI：
10.1093/jnci/djv219
发表时间：
2015-11
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Ben Zhang;X. Shu;Ryan J. Delahanty;Chenjie Zeng;K. Michailidou;M. Bolla;Qin Wang;J. Dennis;W. Wen;J. Long;Chun Li;A. Dunning;J. Chang-Claude;M. Shah;B. Perkins;K. Czene;Hatef Darabi;M. Eriksson;S. Bojesen;B. Nordestgaard;S. F. Nielsen;H. Flyger;D. Lambrechts;P. Neven;H. Wildiers;G. Floris;M. Schmidt;M. Rookus;Katja van den Hurk;Wim L. A. M. de Kort;F. Couch;J. Olson;Emily J. Hallberg;C. Vachon;A. Rudolph;P. Seibold;D. Flesch-Janys;J. Peto;I. dos-Santos-Silva;O. Fletcher;N. Johnson;H. Nevanlinna;T. Muranen;K. Aittomäki;C. Blomqvist;Jingmei Li;K. Humphreys;Judith S. Brand;P. Guénel;Thérèse Truong;E. Cordina-Duverger;F. Menegaux;B. Burwinkel;F. Marmé;Rongxi Yang;H. Surowy;J. Benítez;M. P. Zamora;J. I. Perez;A. Cox;S. Cross;M. Reed;I. Andrulis;J. Knight;G. Glendon;S. Tchatchou;E. Sawyer;I. Tomlinson;M. Kerin;N. Miller;G. Chenevix-Trench;C. Haiman;B. E. Henderson;F. Schumacher;L. Marchand;A. Lindblom;S. Margolin;M. Hooning;John W. M. Martens;M. Tilanus-Linthorst;J. Collée;J. Hopper;M. Southey;H. Tsimiklis;C. Apicella;S. Slager;A. Toland;C. Ambrosone;D. Yannoukakos;Graham G. Giles;R. Milne;C. Mclean;P. Fasching;L. Haeberle;A. Ekici;M. W. Beckmann;H. Brenner;A. K. Dieffenbach;V. Arndt;C. Stegmaier;Anthony J. Swerdlow;A. Ashworth;N. Orr;Michael P. Jones;J. Figueroa;M. García-Closas;L. Brinton;J. Lissowska;M. Dumont;R. Winqvist;K. Pylkäs;A. Jukkola-Vuorinen;Mervi Grip;H. Brauch;T. Brüning;Y. Ko;P. Peterlongo;S. Manoukian;B. Bonanni;P. Radice;N. Bogdanova;N. Antonenkova;T. Dörk;A. Mannermaa;V. Kataja;V. Kosma;Jaana M. Hartikainen;P. Devilee;C. Seynaeve;C. V. van Asperen;A. Jakubowska;J. Lubiński;Katarzyna Jaworska–Bieniek;K. Durda;U. Hamann;Diana Torres;R. Schmutzler;S. Neuhausen;H. Anton-Culver;V. Kristensen;Grethe I. Grenaker Alnæs;B. Pierce;P. Kraft;U. Peters;S. Lindstrom;D. Seminara;S. Burgess;Habibul Ahsan;A. Whittemore;Esther M. John;M. Gammon;K. Malone;D. Tessier;Daniel Vincent;F. Bacot;C. Luccarini;C. Baynes;Shahana Ahmed;M. Maranian;C. Healey;A. González-Neira;G. Pita;M. R. Alonso;N. Álvarez;D. Herrero;Paul D. P. Pharoah;J. Simard;P. Hall;D. J. Hunter;D. Easton;W. Zheng
通讯作者：
Ben Zhang;X. Shu;Ryan J. Delahanty;Chenjie Zeng;K. Michailidou;M. Bolla;Qin Wang;J. Dennis;W. Wen;J. Long;Chun Li;A. Dunning;J. Chang-Claude;M. Shah;B. Perkins;K. Czene;Hatef Darabi;M. Eriksson;S. Bojesen;B. Nordestgaard;S. F. Nielsen;H. Flyger;D. Lambrechts;P. Neven;H. Wildiers;G. Floris;M. Schmidt;M. Rookus;Katja van den Hurk;Wim L. A. M. de Kort;F. Couch;J. Olson;Emily J. Hallberg;C. Vachon;A. Rudolph;P. Seibold;D. Flesch-Janys;J. Peto;I. dos-Santos-Silva;O. Fletcher;N. Johnson;H. Nevanlinna;T. Muranen;K. Aittomäki;C. Blomqvist;Jingmei Li;K. Humphreys;Judith S. Brand;P. Guénel;Thérèse Truong;E. Cordina-Duverger;F. Menegaux;B. Burwinkel;F. Marmé;Rongxi Yang;H. Surowy;J. Benítez;M. P. Zamora;J. I. Perez;A. Cox;S. Cross;M. Reed;I. Andrulis;J. Knight;G. Glendon;S. Tchatchou;E. Sawyer;I. Tomlinson;M. Kerin;N. Miller;G. Chenevix-Trench;C. Haiman;B. E. Henderson;F. Schumacher;L. Marchand;A. Lindblom;S. Margolin;M. Hooning;John W. M. Martens;M. Tilanus-Linthorst;J. Collée;J. Hopper;M. Southey;H. Tsimiklis;C. Apicella;S. Slager;A. Toland;C. Ambrosone;D. Yannoukakos;Graham G. Giles;R. Milne;C. Mclean;P. Fasching;L. Haeberle;A. Ekici;M. W. Beckmann;H. Brenner;A. K. Dieffenbach;V. Arndt;C. Stegmaier;Anthony J. Swerdlow;A. Ashworth;N. Orr;Michael P. Jones;J. Figueroa;M. García-Closas;L. Brinton;J. Lissowska;M. Dumont;R. Winqvist;K. Pylkäs;A. Jukkola-Vuorinen;Mervi Grip;H. Brauch;T. Brüning;Y. Ko;P. Peterlongo;S. Manoukian;B. Bonanni;P. Radice;N. Bogdanova;N. Antonenkova;T. Dörk;A. Mannermaa;V. Kataja;V. Kosma;Jaana M. Hartikainen;P. Devilee;C. Seynaeve;C. V. van Asperen;A. Jakubowska;J. Lubiński;Katarzyna Jaworska–Bieniek;K. Durda;U. Hamann;Diana Torres;R. Schmutzler;S. Neuhausen;H. Anton-Culver;V. Kristensen;Grethe I. Grenaker Alnæs;B. Pierce;P. Kraft;U. Peters;S. Lindstrom;D. Seminara;S. Burgess;Habibul Ahsan;A. Whittemore;Esther M. John;M. Gammon;K. Malone;D. Tessier;Daniel Vincent;F. Bacot;C. Luccarini;C. Baynes;Shahana Ahmed;M. Maranian;C. Healey;A. González-Neira;G. Pita;M. R. Alonso;N. Álvarez;D. Herrero;Paul D. P. Pharoah;J. Simard;P. Hall;D. J. Hunter;D. Easton;W. Zheng
影响因子：
6.9
作者：
Peter, Inga;McCaffery, Jeanne M.;Kelley-Hedgepeth, Alyson;Hakonarson, Hakon;Reis, Steven;Wagenknecht, Lynne E.;Kopin, Alan S.;Huggins, Gondon S.
通讯作者：
Huggins, Gondon S.
影响因子：
8.2
作者：
Yan, Jing;Peng, Danfeng;Jia, Weiping
通讯作者：
Jia, Weiping