Circadian immunity from bench to bedside: a practical guide.
Circadian immunity from bench to bedside: a practical guide.
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DOI：
10.1172/jci175706
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发表时间：
2024-02-01
期刊：
影响因子：
--
通讯作者：
Haspel JA
中科院分区：
文献类型：
--
作者：
Mok H;Ostendorf E;Ganninger A;Adler AJ;Hazan G;Haspel JA
免疫系统的建立是为了抵御不可预测的威胁，但它依赖于可预测的活动周期来正常运作。免疫功能的日常节律是一个不断扩大的研究领域，其中许多源于一种基于基因的计时机制，即生物钟。挑战在于如何利用这些生物节律来改善医疗干预。在这里，我们回顾了最近的文献，记录了生物钟如何组织基本的先天和适应性免疫活动，昼夜节律和睡眠中断的免疫后果，以及该领域持续存在的知识空白。然后我们考虑将昼夜节律与疫苗接种联系起来的证据，这是免疫功能的重要临床实现。最后，我们讨论了将昼夜免疫转化为患者床边的实际步骤。
The immune system is built to counteract unpredictable threats, yet it relies on predictable cycles of activity to function properly. Daily rhythms in immune function are an expanding area of study, and many originate from a genetically based timekeeping mechanism known as the circadian clock. The challenge is how to harness these biological rhythms to improve medical interventions. Here, we review recent literature documenting how circadian clocks organize fundamental innate and adaptive immune activities, the immunologic consequences of circadian rhythm and sleep disruption, and persisting knowledge gaps in the field. We then consider the evidence linking circadian rhythms to vaccination, an important clinical realization of immune function. Finally, we discuss practical steps to translate circadian immunity to the patient’s bedside.
影响因子：
3.5
作者：
Erber, Astrid C.;Wagner, Angelika;Karachaliou, Marianna;Jeleff, Maren;Kalafatis, Polyxeni;Kogevinas, Manolis;Peplonska, Beata;Santonja, Isabel;Schernhammer, Eva;Stockinger, Hannes;Straif, Kurt;Wiedermann, Ursula;Waldhoer, Thomas;Papantoniou, Kyriaki
通讯作者：
Papantoniou, Kyriaki
影响因子：
13.6
作者：
Lee SH;Wan Q;Wentworth A;Ballinger I;Ishida K;Collins JE;Tamang S;Huang HW;Li C;Hess K;Lopes A;Kirtane AR;Lee JS;Lee S;Chen W;Wong K;Selsing G;Kim H;Buckley ST;Hayward A;Langer R;Traverso G
通讯作者：
Traverso G
影响因子：
4
作者：
Samulin Erdem J;Notø HØ;Skare Ø;Lie JS;Petersen-Øverleir M;Reszka E;Pepłońska B;Zienolddiny S
通讯作者：
Zienolddiny S