The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.
The Association of Time of Day of ChAdOx1 nCoV-19 Vaccine Administration With SARS-CoV-2 Anti-Spike IgG Antibody Levels: An Exploratory Observational Study.
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DOI：
10.1177/07487304221132355
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发表时间：
2023-02
影响因子：
3.5
通讯作者：
Papantoniou, Kyriaki
中科院分区：
文献类型：
--
作者：
Erber, Astrid C.;Wagner, Angelika;Karachaliou, Marianna;Jeleff, Maren;Kalafatis, Polyxeni;Kogevinas, Manolis;Peplonska, Beata;Santonja, Isabel;Schernhammer, Eva;Stockinger, Hannes;Straif, Kurt;Wiedermann, Ursula;Waldhoer, Thomas;Papantoniou, Kyriaki
来自人类和动物研究的数据高度暗示了疫苗接种时间对宿主免疫反应的影响。在这项以人群为基础的研究中，我们旨在研究接种新冠肺炎载体疫苗ChAdOx1nCoV-19(阿斯利康)的时间对SARS-CoV-2抗峰值S1免疫球蛋白水平的影响。参与者是803名大学员工，他们在2021年3月接种了第一剂疫苗，在基线和3 周有血清学数据，在基线是血清阴性。抗体水平以结合抗体单位(BAU/m L)为单位，用酶联免疫吸附试验(EL ISA)测定。用广义加性模型和线性回归分析连续接种时间和每小时桶内接种时间与3 周抗体水平的关系。参与者的平均年龄为42 岁(SD：12；范围：21-74)，其中60%为女性。接种疫苗的时间与抗体水平呈非线性关系(“逆J形”)。上午接种的抗体水平最高(9：00-10：00h，平均292.1 BAU/m L；SD：262.1)，下午早接种最低(12：00-13：00 h，平均217.3 BAU/m L；SD：153.6)，下午晚些时候(14：00-15：00 h，平均280.7 BAU/m L；SD：262.4)抗体水平最低。在调整潜在混杂因素后，12：00-13：00h(但不包括其他时间间隔)的抗体水平显著低于9：00-10：00h的免疫(β系数=−75.8，95%可信区间[CI]=−131.3，−2 0.4)。我们的研究结果表明，接种SARS-CoV2疫苗的时间对3 周的抗体水平有影响。这种差异在加强疫苗接种后是否会持续，以及是否会影响对新冠肺炎的保护水平，还需要进一步评估。
Data from human and animal studies are highly suggestive of an influence of time of day of vaccine administration on host immune responses. In this population-based study, we aimed to investigate the effect of time of day of administration of a COVID-19 vector vaccine, ChAdOx1 nCoV-19 (AstraZeneca), on SARS-CoV-2 anti-spike S1 immunoglobulin (IgG) levels. Participants were 803 university employees who received their first vaccine dose in March 2021, had serology data at baseline and at 3 weeks, and were seronegative at baseline. Antibody levels were determined in binding antibody units (BAU/mL) using enzyme-linked immunosorbent assay (ELISA). Generalized additive models (GAM) and linear regression were used to evaluate the association of time of day of vaccination continuously and in hourly bins with antibody levels at 3 weeks. Participants had a mean age of 42 years (SD: 12; range: 21-74) and 60% were female. Time of day of vaccination was associated non-linearly (“reverse J-shape”) with antibody levels. Morning vaccination was associated with the highest (9:00-10:00 h: mean 292.1 BAU/mL; SD: 262.1), early afternoon vaccination with the lowest (12:00-13:00 h: mean 217.3 BAU/mL; SD: 153.6), and late afternoon vaccination with intermediate (14:00-15:00 h: mean 280.7 BAU/mL; SD: 262.4) antibody levels. Antibody levels induced by 12:00-13:00 h vaccination (but not other time intervals) were significantly lower compared to 9:00-10:00 h vaccination after adjusting for potential confounders (beta coefficient = −75.8, 95% confidence interval [CI] = −131.3, −20.4). Our findings show that time of day of vaccination against SARS-CoV-2 has an impact on the magnitude of IgG antibody levels at 3 weeks. Whether this difference persists after booster vaccine doses and whether it influences the level of protection against COVID-19 needs further evaluation.
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影响因子：
7.3
作者：
He Q;Mao Q;Zhang J;Bian L;Gao F;Wang J;Xu M;Liang Z
通讯作者：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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