Mechanisms of breast cancer risk in shift workers: association of telomere shortening with the duration and intensity of night work.
Mechanisms of breast cancer risk in shift workers: association of telomere shortening with the duration and intensity of night work.
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DOI：
10.1002/cam4.1135
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发表时间：
2017-08
期刊：
影响因子：
4
通讯作者：
Zienolddiny S
中科院分区：
文献类型：
--
作者：
Samulin Erdem J;Notø HØ;Skare Ø;Lie JS;Petersen-Øverleir M;Reszka E;Pepłońska B;Zienolddiny S
职业因素，如轮班工作，特别是夜间工作，扰乱了昼夜节律，可能会增加患乳腺癌的风险。昼夜节律紊乱也可能影响端粒长度(TL)。虽然短TL通常与癌症风险增加有关，但它与乳腺癌风险的关系尚不确定。我们认为，工作时间安排可能是评估TL对乳腺癌风险影响的一个重要因素。此外，端粒缩短可能是与夜间工作相关的乳腺癌的一个潜在机制。在这项研究中，在挪威护士的嵌套乳腺癌病例对照研究中，研究了轮班工作对TL的影响及其与乳腺癌风险的关系。用定量聚合酶链式反应(QPCR)检测了563例乳腺癌患者和619例对照DNA中的TL。在这里，我们证明了TL受到密集的夜间工作时间表的影响，因为连续6个晚上工作超过5年与端粒长度减少相关(−3.18，95%CI：−6.46至−0.58，P=0.016)。此外，端粒缩短与长时间连续上夜班的工人患乳腺癌的风险增加有关。因此，端粒长度较长的护士，如果连续工作4次(OR：0.37，95%CI：0.16~0.79，P=0.014)或5次(OR：0.31，95%CI：0.10~0.83，P=0.029)连续上夜班5年或更长时间，患乳腺癌的风险就会降低。这些数据表明，端粒缩短与夜间工作的持续时间和强度有关，可能是女性轮班工人患乳腺癌风险的一个促成因素。
Occupational factors such as shiftwork and especially night work that involves disruption of the circadian rhythm may contribute to increased breast cancer risk. Circadian disruption may also affect telomere length (TL). While short TL generally is associated with increased cancer risk, its association with breast cancer risk is inconclusive. We suggest that working schedules might be an important factor in assessment of effects of TL on breast cancer risk. Moreover, telomere shortening might be a potential mechanism for night work‐related breast cancer. In this study, effects of shift work on TL and its association with breast cancer risk were investigated in a nested breast cancer case–control study of Norwegian nurses. TL was assessed by qPCR in DNA from 563 breast cancer patients and 619 controls. Here, we demonstrate that TL is affected by intensive night work schedules, as work with six consecutive night for a period of more than 5 years was associated with decreased telomere lengths (−3.18, 95% CI: −6.46 to −0.58, P = 0.016). Furthermore, telomere shortening is associated with increased breast cancer risk in workers with long periods of consecutive night shifts. Thus, nurses with longer telomere lengths had a lower risk for breast cancer if they had worked more than four (OR: 0.37, 95% CI: 0.16–0.79, P = 0.014) or five (OR: 0.31, 95% CI: 0.10–0.83, P = 0.029) consecutive night shifts for a period of 5 years or more. These data suggest that telomere shortening is associated with the duration and intensity of night work and may be a contributing factor for breast cancer risk among female shift workers.
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影响因子：
3.7
作者：
Liang G;Schernhammer E;Qi L;Gao X;De Vivo I;Han J
通讯作者：
Han J
DOI：
10.1158/1055-9965.epi-08-0935
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kim S;Parks CG;DeRoo LA;Chen H;Taylor JA;Cawthon RM;Sandler DP
通讯作者：
Sandler DP
影响因子：
4.9
作者：
Hansen, Johnni;Lassen, Christina F.
通讯作者：
Lassen, Christina F.
在前瞻性病例 - 霍特分析中，外周血和乳腺癌风险的端粒长度：姐妹研究的结果。
影响因子：
2.3
作者：
Kim, Sangmi;Sandler, Dale P.;Carswell, Gleta;De Roo, Lisa A.;Parks, Christine G.;Cawthon, Richard;Weinberg, Clarice R.;Taylor, Jack A.
通讯作者：
Taylor, Jack A.
影响因子：
30.8
作者：
通讯作者：
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