Brain-derived neurotrophic factor in primary headaches.
Brain-derived neurotrophic factor in primary headaches.
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DOI：
10.1007/s10194-012-0454-5
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发表时间：
2012-08
影响因子：
7.4
通讯作者：
Broessner, Gregor
中科院分区：
文献类型：
--
作者：
Fischer, Marlene;Wille, Georg;Klien, Stephanie;Shanib, Hind;Holle, Dagny;Gaul, Charly;Broessner, Gregor
脑源性神经营养因子 (BDNF) 与疼痛调节和中枢敏化相关。最近，由于 BDNF 与降钙素基因相关肽的已知相互作用，人们怀疑 BDNF 在偏头痛和丛集性头痛病理生理学中的作用。双中心前瞻性研究纳入了四个诊断组：有先兆和无先兆的阵发性偏头痛、阵发性丛集性头痛、频繁阵发性紧张型头痛和健康个体。在偏头痛患者中，采集了两次静脉血样本：在偏头痛发作期间和服用止痛药之前。在丛集性头痛患者中，在丛集性头痛发作期间和发作期间收集血清样本。使用酶联免疫吸附测定技术进行 BDNF 分析。与无头痛间隔期 (n = 53，P < 0.01)、紧张型头痛患者 (n = 6，P < 0.05) 和健康对照 (n = 22，P < 0.001) 相比，偏头痛患者在偏头痛发作期间 (n = 25) 的 BDNF 血清水平显着升高。无论是在偏头痛发作期间还是在无头痛期间，有先兆偏头痛患者与无先兆偏头痛患者之间没有显着差异。与健康对照组相比，丛集性头痛患者在丛集性头痛发作内 (n = 42) 和丛集性发作外 (n = 24) 表现出显着较高的 BDNF 浓度 (P < 0.01，P < 0.05)。 BDNF 在偏头痛发作期间和丛集性头痛中增加，进一步支持 BDNF 参与这些原发性头痛的病理生理学。
Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide. Bi-center prospective study was done enrolling four diagnostic groups: episodic migraine with and without aura, episodic cluster headache, frequent episodic tension-type headache, and healthy individuals. In migraineurs, venous blood samples were collected twice: outside and during migraine attacks prior to pain medication. In cluster headache patients serum samples were collected in and outside cluster bout. Analysis of BDNF was performed using enzyme-linked immunosorbent assay technique. Migraine patients revealed significantly higher BDNF serum levels during migraine attacks (n = 25) compared with headache-free intervals (n = 53, P < 0.01), patients with tension-type headache (n = 6, P < 0.05), and healthy controls (n = 22, P < 0.001). There was no significant difference between patients with migraine with aura compared with those without aura, neither during migraine attacks nor during headache-free periods. Cluster headache patients showed significantly higher BDNF concentrations inside (n = 42) and outside cluster bouts (n = 24) compared with healthy controls (P < 0.01, P < 0.05). BDNF is increased during migraine attacks, and in cluster headache, further supporting the involvement of BDNF in the pathophysiology of these primary headaches.
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影响因子：
3.3
作者：
Balkowiec-Iskra, E.;Vermehren-Schmaedick, A.;Balkowiec, A.
通讯作者：
Balkowiec, A.
影响因子：
4.9
作者：
Blandini, F;Rinaldi, L;Leon, A
通讯作者：
Leon, A
影响因子：
2.3
作者：
Lipton, R B;Stewart, W F;Scher, A I
通讯作者：
Scher, A I
影响因子：
2.5
作者：
Cirulli, F;Berry, A;Alleva, E
通讯作者：
Alleva, E
影响因子：
7.4
作者：
DiPiero, V;Fiacco, F;Pantano, P
通讯作者：
Pantano, P