The structure of cytoplasm in directly frozen cultured cells. II. Cytoplasmic domains associated with organelle movements.
The structure of cytoplasm in directly frozen cultured cells. II. Cytoplasmic domains associated with organelle movements.
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DOI：
10.1083/jcb.102.4.1510
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发表时间：
1986-04
期刊：
影响因子：
--
通讯作者：
Reese TS
中科院分区：
文献类型：
--
作者：
Bridgman PC;Kachar B;Reese TS
本文用视频增强微分干涉显微镜和直接冷冻的电镜研究了培养的成纤维细胞或上皮细胞的细胞器运动与细胞质结构之间的关系。两个功能性胞质结构域的特征在于这些技术。一个中央域丰富的微管与定向以及布朗运动的细胞器，而周围的域丰富的f-肌动蛋白支持定向，但往往间歇性的细胞器运动更远沿着小，但不同的个别微管轨道。微管附近的细胞质组织的差异可以解释为什么细胞器的运动在中心区域通常是连续的，但通常是间歇性的沿着通过周边的小轨道。中央型细胞质的细胞骨架网比周围型细胞质的细胞骨架网更疏松，因此，周围型细胞质对沿沿着微管运动的细胞器的干扰较少。
The relationship between organelle movement and cytoplasmic structure in cultured fibroblasts or epithelial cells was studied using video- enhanced differential interference contrast microscopy and electron microscopy of directly frozen whole mounts. Two functional cytoplasmic domains are characterized by these techniques. A central domain rich in microtubules is associated with directed as well as Brownian movements of organelles, while a surrounding domain rich in f-actin supports directed but often intermittent organelle movements more distally along small but distinct individual microtubule tracks. Differences in the organization of the cytoplasm near microtubules may explain why organelle movements are typically continuous in central regions but usually intermittent along the small tracks through the periphery. The central type of cytoplasm has a looser cytoskeletal meshwork than the peripheral cytoplasm which might, therefore, interfere less frequently with organelles moving along microtubules there.
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