Heritable remodeling of yeast multicellularity by an environmentally responsive prion.
Heritable remodeling of yeast multicellularity by an environmentally responsive prion.
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DOI：
10.1016/j.cell.2013.02.026
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发表时间：
2013-03-28
期刊：
影响因子：
64.5
通讯作者：
Halfmann R
中科院分区：
文献类型：
--
作者：
Holmes DL;Lancaster AK;Lindquist S;Halfmann R
Prion蛋白经历自我维持的构象转换，从而遗传地改变其活性。其中许多蛋白质在决定基因如何转化为表型的过程中起着关键作用。但普恩对生物学的广泛影响以及它们的进化意义才刚刚开始被探索。我们报道了由mot3转录因子[mot3+]形成的Prion控制着萌芽酵母兼性多细胞的获得。由[mot3+]支配的特征涉及mot3调控活动的得失。[mot3+]依赖的FLO11的表达是细胞-细胞黏附的主要决定因素，在营养剥夺的反应中产生不同的谱系特异性的多细胞表型。在酵母菌种群的自然呼吸循环中，PrP本身被乙醇诱导，并被低氧条件消除--这些条件是顺序发生的。这些数据表明，Prion可以作为多细胞的环境响应性分子决定因素，并有助于芽殖酵母的自然形态多样性。
Prion proteins undergo self-sustaining conforma-tional conversions that heritably alter their activities. Many of these proteins operate at pivotal positions in determining how genotype is translated into pheno-type. But the breadth of prion influences on biology and their evolutionary significance are just beginning to be explored. We report that a prion formed by the Mot3 transcription factor, [MOT3+], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cerevisiae. The traits governed by [MOT3+] involved both gains and losses of Mot3 regulatory activity. [MOT3+]-dependent expression of FLO11, a major determinant of cell-cell adhesion, produced diverse lineage-specific multicellular phenotypes in response to nutrient deprivation. The prions themselves were induced by ethanol and eliminated by hypoxia—conditions that occur sequentially in the natural respiro-fermen-tative cycles of yeast populations. These data demonstrate that prions can act as environmentally responsive molecular determinants of multicellularity and contribute to the natural morphological diversity of budding yeast.
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