3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy.
3D viability imaging of tumor phantoms treated with single-walled carbon nanohorns and photothermal therapy.
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DOI：
10.1088/0957-4484/24/27/275102
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发表时间：
2013-07-12
期刊：
影响因子：
3.5
通讯作者：
Rylander MN
中科院分区：
文献类型：
--
作者：
Whitney J;DeWitt M;Whited BM;Carswell W;Simon A;Rylander CG;Rylander MN
提出了一种新的图像分析方法，称为层中细胞热响应的空间体模评估（SPECTRL），用于评估组织代表性体模中纳米颗粒增强光热治疗的空间存活率响应。用镱纤维激光器在1064 nm的波长和3.8瓦/cm 2的辐照度下对接种有MDA-MB-231乳腺癌细胞和单壁纳米角的藻酸钠模型进行激光辐照10-80秒。SPECTRL定量评估并将3D生存能力与时空温度相关联。基于该分析，随着持续时间从10秒增加到80秒，杀伤区和过渡区分别从3.7 mm 3和13 mm 3增加到44.5 mm 3和44.3 mm 3。SPECTRL提供了一种用于测量精确空间治疗区域的定量工具，提供了定制治疗方案所需的信息。
A new image analysis method called the Spatial Phantom Evaluation of Cellular Thermal Response in Layers (SPECTRL) is presented for assessing spatial viability response to nanoparticle enhanced photothermal therapy in tissue representative phantoms. Sodium alginate phantoms seeded with MDA-MB-231 breast cancer cells and single walled nanohorns were laser irradiated with an ytterbium fiber laser at a wavelength of 1064 nm and irradiance of 3.8 watts/cm2 for 10–80 seconds. SPECTRL quantitatively assessed and correlated 3D viability with spatiotemporal temperature. Based on this analysis, kill and transition zones increased from 3.7 mm3 and 13 mm3 respectively to 44.5 mm3 and 44.3 mm3 as duration was increased from 10–80 seconds. SPECTRL provides a quantitative tool for measuring precise spatial treatment regions, providing information necessary to tailor therapy protocols.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
4.9
作者：
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3
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DOI：
10.1007/s10856-007-3091-9
发表时间：
2007-10-01
影响因子：
3.7
作者：
Garcia, Y.;Collighan, R.;Pandit, A.
通讯作者：
Pandit, A.
影响因子：
48
作者：
Fischbach, Claudia;Chen, Ruth;Mooney, David J.
通讯作者：
Mooney, David J.