Effects of insomnia disorder and knee osteoarthritis on resting and pain-evoked inflammatory markers.
Effects of insomnia disorder and knee osteoarthritis on resting and pain-evoked inflammatory markers.
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DOI：
10.1016/j.bbi.2014.12.010
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发表时间：
2015-07
影响因子：
15.1
通讯作者：
Smith, Michael T.
中科院分区：
文献类型：
--
作者：
Quartana, Phillip J.;Finan, Patrick H.;Page, Gayle G.;Smith, Michael T.
骨关节炎是最普遍的关节炎病症。全身性炎性细胞因子似乎在疾病的发生和维持中起重要作用。睡眠障碍在骨关节炎中普遍存在，并与全身炎性细胞因子的改变相关，表明这些疾病有共同的病理生理学。失眠症和骨关节炎对疼痛诱发的细胞因子反应的影响的比较研究尚未进行。我们研究了症状性膝关节骨关节炎和失眠症对静息C反应蛋白（CRP）、白细胞介素（IL）-6和IL-10水平以及疼痛诱发的IL-6和IL-10反应的影响。参与者为N = 117名老年人（平均年龄= 59.7岁; 61.8%为女性），使用既定的诊断指南对膝关节骨关节炎和失眠症进行严格评估。结果显示，骨关节炎或失眠症与CRP无关。骨关节炎参与者的静息IL-6高于无骨关节炎的参与者，尽管这种关联在很大程度上归因于BMI。IL-10在患有骨关节炎或失眠症的参与者中最高。生长曲线模型显示，与没有失眠症或骨关节炎的参与者相比，患有失眠症的参与者有更大的疼痛诱发的IL-6反应。这些发现强调了实验室疼痛测试方法在了解炎症细胞因子个体差异方面的实用性。此外，我们的研究结果为临床诊断为失眠症的老年人中疼痛诱发的促炎细胞因子反应性放大提供了证据，即使在控制了BMI和年龄的个体差异之后。还需要进一步的研究来确定疼痛相关的细胞因子反应是否会导致OA，以及可能与失眠症相关的其他年龄相关疾病。
Osteoarthritis is the most prevalent arthritic condition. Systemic inflammatory cytokines appear to have an important role in the onset and maintenance of the disease. Sleep disturbances are prevalent in osteoarthritis and associated with alterations in systemic inflammatory cytokines, suggesting a common pathophysiology across these conditions. A comparative investigation of the effects of insomnia disorder and osteoarthritis on pain-evoked cytokine responses has yet to be undertaken. We examined the influence of symptomatic knee osteoarthritis and insomnia disorder on resting C-reactive protein (CRP), interleukin (IL)-6, and IL-10 levels, and pain-evoked IL-6 and IL-10 responses. Participants were N = 117 older adults (mean age = 59.7 years; 61.8% women) rigorously evaluated for knee osteoarthritis and insomnia disorder using established diagnostic guidelines. Results revealed no association of osteoarthritis or insomnia disorder with CRP. Resting IL-6 was greater in osteoarthritis participants versus those without osteoarthritis, although this association was largely attributable to BMI. IL-10 was highest among participants with osteoarthritis or insomnia disorder. Growth curve modeling revealed that participants with insomnia disorder had greater pain-evoked IL-6 responses than participants without insomnia disorder or osteoarthritis. These findings highlight the utility of laboratory pain testing methods for understanding individual differences in inflammatory cytokines. Moreover, our findings provide evidence for amplified pain-evoked pro-inflammatory cytokine reactivity among older adults with clinically diagnosed insomnia disorder, even after controlling for individual differences in BMI and age. Additional research will be required determine whether an amplified pain-related cytokine response contributes to OA, and possibly other age-related disease, associated with insomnia disorder.
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影响因子：
2.6
作者：
Brydon, Lena
通讯作者：
Brydon, Lena
影响因子：
8.2
作者：
Dickerson SS;Gable SL;Irwin MR;Aziz N;Kemeny ME
通讯作者：
Kemeny ME
DOI：
10.1093/gerona/gln038
发表时间：
2009-04-01
影响因子：
5.1
作者：
Brinkley, Tina E.;Leng, Xiaoyan;Nicklas, Barbara J.
通讯作者：
Nicklas, Barbara J.
影响因子：
15.1
作者：
Burgos, I;Richter, L;Riemann, D
通讯作者：
Riemann, D
影响因子：
4.8
作者：
Bastien, Celyne H.;Vallieres, Annie;Morin, Charles M.
通讯作者：
Morin, Charles M.