Adiposity, leptin and stress reactivity in humans.
Adiposity, leptin and stress reactivity in humans.
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DOI：
10.1016/j.biopsycho.2010.02.010
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发表时间：
2011-02
影响因子：
2.6
通讯作者：
Brydon, Lena
中科院分区：
文献类型：
--
作者：
Brydon, Lena
有证据表明，更肥胖的人可能对压力更敏感。压力激活交感神经系统（SNS）和脂肪组织细胞因子瘦素刺激动物的SNS活动。我们研究了67名女性肥胖、瘦素和对急性实验室应激的生理反应之间的关系。我们预测，肥胖和/或血浆瘦素水平较高的个体对压力反应更敏感。肥胖与心血管或神经内分泌应激反应无关。然而，腰围较大的女性有更大的压力诱导的血浆瘦素和白细胞介素-1受体拮抗剂（IL-1 Ra）的增加。同样，基础瘦素水平较高的女性，应激诱导的心率和血浆白细胞介素-6增加更大，心率变异性和心脏射血前期下降更大。心血管和炎症应激反应的升高可预测未来的心血管风险。我们的研究结果表明，细胞因子瘦素和IL-1 Ra可能在肥胖，压力和心血管健康之间的关联中发挥作用。
Evidence suggests that individuals who are more obese may be more responsive to stress. Stress activates the sympathetic nervous system (SNS) and the adipose-tissue cytokine leptin stimulates SNS activity in animals. We examined the relationship between adiposity, leptin and physiological responses to acute laboratory stress in 67 women. We predicted that individuals with greater adiposity and/or higher plasma leptin would be more stress-responsive. Adiposity was unrelated to cardiovascular or neuroendocrine stress reactivity. However, women with larger waists had greater stress-induced increases in plasma leptin and interleukin-1 receptor antagonist (IL-1Ra). Similarly, women with higher basal leptin displayed greater stress-induced increases in heart rate and plasma interleukin-6, and larger decreases in heart rate variability and cardiac pre-ejection period. Heightened cardiovascular and inflammatory stress responses are predictive of future cardiovascular risk. Our findings suggest that the cytokines leptin and IL-1Ra may play a role in the association between obesity, stress and cardiovascular health.
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