Financial strain is associated with increased oxidative stress levels: the Women's Health and Aging Studies.
Financial strain is associated with increased oxidative stress levels: the Women's Health and Aging Studies.
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DOI：
10.1016/j.gerinurse.2015.02.020
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Fried LP
中科院分区：
文献类型：
--
作者：
Palta P;Szanton SL;Semba RD;Thorpe RJ;Varadhan R;Fried LP
氧化应激水平升高可能是导致不良健康结局的潜在生物学机制之一，包括动脉粥样硬化和糖尿病。成年后的经济压力总是与健康状况不佳联系在一起。高氧化应激和经济压力都是发病率和死亡率的预测因素，但很少有研究调查它们之间的关系。这项研究调查了经济压力是否与氧化应激水平升高有关。在基线访问时，对来自妇女健康和老龄化研究I和II的728名居住在社区的老年妇女进行了横断面分析。通过线性回归来量化财务压力和氧化应激之间的关系。氧化应激是使用从血清样本中获得的蛋白质羰基浓度来测量的。财务压力被衡量为三个层次的顺序反应：“在月底，你的钱是够多的、刚刚够的还是不够的？”那些报告高财务压力的人与报告低财务压力的人相比，蛋白质羰基浓度高13.4%(p=0.002)。研究结果表明，居住在社区的老年女性的高经济压力可能与氧化应激增加有关，这表明氧化应激可能在经济压力和糟糕的健康结果之间发挥中介作用。这些结果至关重要，因为来自较低社会经济地位背景的个体始终表现出较差的健康结果。
Elevated oxidative stress levels may be one underlying biological mechanism that contributes to poor health outcomes, including atherosclerosis and diabetes. Financial strain in adulthood is consistently associated with poor health. High oxidative stress and financial strain are each predictors of morbidity and mortality, but little research has investigated their relationship. This study investigated whether financial strain was associated with elevated oxidative stress levels. A cross-sectional analysis was conducted on 728 community-dwelling older adult women from the Women’s Health and Aging Studies I and II at the baseline visit. Linear regression was performed to quantify the relationship between financial strain and oxidative stress. Oxidative stress was measured using protein carbonyl concentrations obtained from serum samples. Financial strain was measured as three-level ordinal response to: “At the end of the month, do you have more than enough money left over, just enough, or not enough?” Those who reported high financial strain exhibited 13.4% higher protein carbonyl concentrations compared to individuals who reported low financial strain (p= 0.002). Findings show that high financial strain among community-dwelling older adult women may be associated with increased oxidative stress, suggesting that oxidative stress could mediate the associations between financial strain and poor health outcomes. These results are of critical importance because individuals from lower SES backgrounds consistently exhibit poorer health outcomes.
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影响因子：
5.7
作者：
Friedman, SM;Steinwachs, DM;Mukamel, DB
通讯作者：
Mukamel, DB
影响因子：
4.8
作者：
Machowetz, Anja;Poulsen, Henrik E.;Koebnick, Corinna
通讯作者：
Koebnick, Corinna
DOI：
10.1097/00005768-200205000-00014
发表时间：
2002-05-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Covas, MI;Elosua, R;Marrugat, J
通讯作者：
Marrugat, J
DOI：
10.1093/geronb/54b.5.s262
发表时间：
1999-09-01
影响因子：
6.2
作者：
Carlson, MC;Fried, LP;Brandt, J
通讯作者：
Brandt, J
影响因子：
4.9
作者：
Raij, L;DeMaster, EG;Jaimes, EA
通讯作者：
Jaimes, EA