The Genus Enterococcus: Between Probiotic Potential and Safety Concerns-An Update.
The Genus Enterococcus: Between Probiotic Potential and Safety Concerns-An Update.
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DOI：
10.3389/fmicb.2018.01791
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发表时间：
2018
影响因子：
5.2
通讯作者：
Hammami R
中科院分区：
文献类型：
--
作者：
Hanchi H;Mottawea W;Sebei K;Hammami R
属于不同种类肠球菌的相当数量的菌株由于对广泛的pH和温度范围的耐受性而具有很强的竞争力。它们的竞争力也归功于它们生产细菌素的能力，细菌素因其对病原菌和腐败菌的广泛有效性而被公认。肠球菌细菌素作为天然抗菌剂在食品工业中引起了极大的研究兴趣，并作为一种潜在的候选药物来取代抗生素治疗多重耐药病原体。然而，毒力因子和抗生素耐药基因的流行以及致病能力可能会影响它们在食品、人类和动物健康中的应用。从目前的监管角度来看，肠球菌属既不被推荐列入QPS名单，也不具有GRAS地位。虽然分子生物学的最新进展和肠球菌菌株安全性评估的推荐方法允许区分共生和临床分支，但仍需要开发高度适应的方法和立法。在本综述中，我们对肠球菌属的某些方面进行了评价。与它们的益生菌特性和安全问题有关，以及在食品系统和感染治疗中的当前和潜在应用。还讨论了食品、饲料、益生菌使用的候选共生肠球菌的监管状况，以及评估和确保其安全性的推荐方法。
A considerable number of strains belonging to different species of Enterococcus are highly competitive due to their resistance to wide range of pH and temperature. Their competitiveness is also owed to their ability to produce bacteriocins recognized for their wide-range effectiveness on pathogenic and spoilage bacteria. Enterococcal bacteriocins have attracted great research interest as natural antimicrobial agents in the food industry, and as a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens. However, the prevalence of virulence factors and antibiotic-resistance genes and the ability to cause disease could compromise their application in food, human and animal health. From the current regulatory point of view, the genus Enterococcus is neither recommended for the QPS list nor have GRAS status. Although recent advances in molecular biology and the recommended methods for the safety evaluation of Enterococcus strains allowed the distinction between commensal and clinical clades, development of highly adapted methods and legislations are still required. In the present review, we evaluate some aspects of Enterococcus spp. related to their probiotic properties and safety concerns as well as the current and potential application in food systems and treatment of infections. The regulatory status of commensal Enterococcus candidates for food, feed, probiotic use, and recommended methods to assess and ensure their safety are also discussed.
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影响因子：
--
作者：
Arqués JL;Rodríguez E;Langa S;Landete JM;Medina M
通讯作者：
Medina M
影响因子：
4.4
作者：
Cao, G. T.;Zeng, X. F.;Yang, C. M.
通讯作者：
Yang, C. M.
影响因子：
3.9
作者：
Avram-Hananel, Liraz;Stock, Julia;Schwartz, Betty
通讯作者：
Schwartz, Betty
DOI：
10.1016/j.ijantimicag.2016.11.016
发表时间：
2017-03-01
影响因子：
10.8
作者：
Caly, Delphine L.;Chevalier, Mickael;Drider, Djamel
通讯作者：
Drider, Djamel
影响因子：
2.6
作者：
Acuna, Leonardo;Picariello, Gianluca;Sesma, Fernando;Morero, Roberto D.;Bellomio, Augusto
通讯作者：
Bellomio, Augusto