COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism.
COVID-19 Infection Enhances Susceptibility to Oxidative Stress-Induced Parkinsonism.
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COVID-19感染增加了对氧化应激诱导的帕金森综合征的易感性。
DOI：
10.1002/mds.29116
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发表时间：
2022-07
影响因子：
8.6
通讯作者：
Schmidt, Peter
中科院分区：
文献类型：
--
作者：
Smeyne, Richard J.;Eells, Jeffrey B.;Chatterjee, Debotri;Byrne, Matthew;Akula, Shaw M.;Sriramula, Srinivas;O'Rourke, Dorcas P.;Schmidt, Peter
由于在1918年流感大流行后诊断为昏睡性脑炎的患者中观察到帕金森样特征，因此神经系统综合征的病毒诱导一直是一个问题。鉴于严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）感染后的全身反应与大流行性流感后观察到的全身反应相似，存在一个问题，即2019年冠状病毒病感染后是否会出现类似的脑后帕金森综合征。这项研究的目的是确定先前感染SARS-CoV-2是否会增加对已知诱导帕金森症的线粒体毒素的敏感性。用SARS-CoV-2感染K18-hACE 2小鼠以诱导轻度至中度疾病。恢复38天后，向小鼠给予非损伤诱导剂量的帕金森毒素1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP），并在7天后实施安乐死。随后的神经炎症和黑质丘脑部（SNpc）多巴胺能（DA）神经元损失被确定，并与SARS-CoV-2或MPTP单独进行比较。感染SARS-CoV-2或MPTP的K18-hACE 2小鼠在MPTP后未显示SNpc DA神经元损失。在SARS-CoV-2感染和恢复的小鼠中，MPTP诱导的SNpc DA神经元损失分别比SARS-CoV-2或MPTP高23%或19%（P < 0.05）。对小胶质细胞活化的检查显示，与SARS-CoV-2或MPTP单独使用相比，SARS-CoV-2 + MPTP组的SNpc和纹状体中活化的小胶质细胞数量显著增加。考虑到SARS-CoV-2感染后幸存的人数，我们的观察结果对长期公共卫生以及未来有关减轻感染的公共政策具有重要影响。然而，确定其他已知增加PD风险的药物是否也与SARS-CoV-2具有协同作用并通过疫苗接种消除将至关重要。版权所有© 2022作者。运动障碍由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版 7月信息图：COVID-19感染增强了对氧化应激诱导的帕金森症的易感性
Viral induction of neurological syndromes has been a concern since parkinsonian‐like features were observed in patients diagnosed with encephalitis lethargica subsequent to the 1918 influenza pandemic. Given the similarities in the systemic responses after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection with those observed after pandemic influenza, there is a question whether a similar syndrome of postencephalic parkinsonism could follow coronavirus disease 2019 infection. The goal of this study was to determine whether prior infection with SARS‐CoV‐2 increased sensitivity to a mitochondrial toxin known to induce parkinsonism. K18‐hACE2 mice were infected with SARS‐CoV‐2 to induce mild‐to‐moderate disease. After 38 days of recovery, mice were administered a non‐lesion‐inducing dose of the parkinsonian toxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and euthanized 7 days later. Subsequent neuroinflammation and substantia nigra pars compacta (SNpc) dopaminergic (DA) neuron loss were determined and compared with SARS‐CoV‐2 or MPTP alone. K18‐hACE2 mice infected with SARS‐CoV‐2 or MPTP showed no SNpc DA neuron loss after MPTP. In mice infected and recovered from SARS‐CoV‐2 infection, MPTP induced a 23% or 19% greater loss of SNpc DA neurons than SARS‐CoV‐2 or MPTP, respectively (P < 0.05). Examination of microglial activation showed a significant increase in the number of activated microglia in both the SNpc and striatum of the SARS‐CoV‐2 + MPTP group compared with SARS‐CoV‐2 or MPTP alone. Our observations have important implications for long‐term public health, given the number of people who have survived SARS‐CoV‐2 infection, as well as for future public policy regarding infection mitigation. However, it will be critical to determine whether other agents known to increase risk for PD also have synergistic effects with SARS‐CoV‐2 and are abrogated by vaccination. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society July Infographic : COVID‐19 Infection Enhances Susceptibility to Oxidative Stress–Induced Parkinsonism
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影响因子：
29
作者：
Cocoros, Noelle M.;Svensson, Elisabeth;Henderson, Victor W.
通讯作者：
Henderson, Victor W.
影响因子：
2.9
作者：
Luchtman, Dirk W.;Shao, Di;Song, Cai
通讯作者：
Song, Cai
DOI：
10.1016/j.dsx.2020.04.020
发表时间：
2020-07-01
影响因子：
10
作者：
Astuti, Indwiani;Ysrafil
通讯作者：
Ysrafil
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影响因子：
16.2
作者：
Da Mesquita S;Fu Z;Kipnis J
通讯作者：
Kipnis J
影响因子：
64.8
作者：
Kobasa, Darwyn;Jones, Steven M.;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro