White matter tracts that overlap with the thalamus and the putamen are protected against multiple sclerosis pathology.
White matter tracts that overlap with the thalamus and the putamen are protected against multiple sclerosis pathology.
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DOI：
10.1016/j.msard.2021.103430
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发表时间：
2022-01
影响因子：
4
通讯作者：
Bagnato, F.
中科院分区：
文献类型：
--
作者：
Clarke, M. A.;Archer, D.;Yoon, K.;Oguz, I;Smith, S. A.;Xu, J.;Cutter, G.;Bagnato, F.
丘脑和壳核是高度连接的中枢，与多发性硬化症 (MS) 病理有关。目前尚不清楚穿过白质 (WM) 束是否对多发性硬化症病理具有不同的易感性，如果是这样，它们对残疾的影响是否比其他 WM 束中的疾病所造成的影响更大。我们假设，由于逆行和顺行远处变性，连接到并穿过这些中枢的 WM 束（随后称为中枢+束）比不穿过这些中枢的束（中枢-束）更容易受到 MS 相关病理的影响。因此，我们比较了 hub+ 束和 hub− 束之间的病变负荷和神经突定向分散和密度成像 (NODDI) 导出指标，并评估了这些 MRI 指标与身体损伤指标之间的关系。 18 名患者（平均年龄 45.5 岁，12 名女性）接受了 3 次 Tesla MRI，包括 T1 加权和 T2 加权流体衰减反转恢复 (FLAIR) 和 NODDI，从中得出方向分散指数 (ODI)、神经突密度指数 (NDI) 和各向同性体积分数 (IVF)。分割出 49 个 WM 束，即 12 个 hub+ 束和 37 个 hub− 束。使用 Mann-Whitney U 检验对两种类型的纤维束之间的病变负担、整个纤维束和正常出现的 WM (NAWM) NODDI 指标的差异进行了探索性分析。使用 Spearman 相关分析评估与身体损伤的相关性，使用扩展残疾状态量表 (EDSS) 和定时 25 英尺步行 (T25FW) 进行评估。 Hub−束具有较大的T1-（p<0.001）和T2-病变（p<0.001）体积；与 hub+ 束相比，ODI 较低（p<0.001）、NDI（p<0.001），IVF 较高（p=0.020）。中枢+束中组织损伤的测量与临床残疾的相关性，尽管不如中枢-束中的强烈。与我们的假设相反，我们的探索性试点研究结果表明，与丘脑和壳核重叠的 WM 束具有较低程度的病变和非病变组织损伤，这表明中枢对 MS 病理具有保护作用，或者那些不经过中枢站的人更容易受到伤害。我们还发现，与中枢-束相比，残疾损伤与中枢+病理之间的关联较弱。我们的研究结果表明，疾病位置与中心相关的潜在作用可以作为多发性硬化症个性化治疗的指导。
The thalamus and the putamen are highly connected hubs implicated in multiple sclerosis (MS) pathology. It remains unclear if white matter (WM) tracts, which pass through them have a different susceptibility to MS pathology, and if so, if their impact on disability predominates over that exerted by disease in other WM tracts. We hypothesized that WM tracts connected to and passing through these hubs (subsequently termed hub+ tracts) would be more susceptible to MS-related pathology than tracts that do not pass through them (hub− tracts) due to retrograde and anterograde distant degeneration. Thus, we compared the lesion load and neurite orientation dispersion and density imaging (NODDI) derived metrics between hub+ and hub− tracts and assessed the relationship between these MRI metrics and those of physical impairment. Eighteen patients (mean age of 45.5 years, 12 females) had 3 Tesla MRI consisting of T1-weighted and T2-weighted Fluid Attenuated Inversion recovery (FLAIR), and NODDI from which the orientation dispersion index (ODI), neurite density index (NDI), and isotropic volume fraction (IVF) were derived. Forty-nine WM tracts, i.e., 12 hub+ and 37 hub− tracts, were segmented out. Exploratory analyses of the differences in lesion burden, whole tract and normal appearing WM (NAWM) NODDI metrics were carried out between the two types of tracts using a Mann-Whitney U test. Correlations with physical impairment, assessed using the expanded disability status scale (EDSS) and timed 25-foot walk (T25FW), were assessed using Spearman correlation analyses. Hub− tracts had larger T1- (p<0.001) and T2-lesion (p<0.001) volumes; lower ODI (p<0.001), NDI (p<0.001) and higher IVF (p=0.020) in comparison to hub+ tracts. Measures of tissue injury in hub+ tracts correlated with those of clinical disability, though less strongly than in hub− tracts. Contrary to our hypothesis, our exploratory pilot study results suggest that WM tracts that overlap with the thalamus and the putamen have a lower degree of lesional and non-lesional tissue injury, suggesting a protective role of the hubs against MS pathology or a higher degree of vulnerability of those not passing through hub stations. We also show a weaker association between disability impairment and hub+ pathology, compared to that in hub− tracts. Our findings point to a potential role of disease location in relation to hubs as guidance for treatment personalization in MS.
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影响因子：
3.7
作者：
Archer, Derek B.;Vaillancourt, David E.;Coombes, Stephen A.
通讯作者：
Coombes, Stephen A.
影响因子：
4.2
作者：
Archer, Derek B.;Moore, Elizabeth E.;Hohman, Timothy J.
通讯作者：
Hohman, Timothy J.
影响因子：
17.7
作者：
Frazier, JA;Chiu, SF;Biederman, J
通讯作者：
Biederman, J
多发性硬化症中区域灰质萎缩的进展。
DOI：
10.1093/brain/awy088
发表时间：
2018-06-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Eshaghi A;Marinescu RV;Young AL;Firth NC;Prados F;Jorge Cardoso M;Tur C;De Angelis F;Cawley N;Brownlee WJ;De Stefano N;Laura Stromillo M;Battaglini M;Ruggieri S;Gasperini C;Filippi M;Rocca MA;Rovira A;Sastre-Garriga J;Geurts JJG;Vrenken H;Wottschel V;Leurs CE;Uitdehaag B;Pirpamer L;Enzinger C;Ourselin S;Gandini Wheeler-Kingshott CA;Chard D;Thompson AJ;Barkhof F;Alexander DC;Ciccarelli O
通讯作者：
Ciccarelli O
影响因子：
5.6
作者：
Krämer J;Meuth SG;Tenberge JG;Schiffler P;Wiendl H;Deppe M
通讯作者：
Deppe M