Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.
Comparison of response properties of the electrically stimulated auditory nerve reported in human listeners and in animal models.
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DOI：
10.1016/j.heares.2022.108643
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发表时间：
2022-12
期刊：
影响因子：
2.8
通讯作者：
He, Shuman
中科院分区：
文献类型：
--
作者：
Skidmore, Jeffrey;Ramekers, Dyan;Bruce, Ian C.;He, Shuman
关键词：
耳蜗植入体（CI）通过电刺激附近的听觉神经纤维（ANF）向植入患者提供声学信息，然后将信息传输到更高级别的神经结构进行进一步处理和解释。模拟ANF对CI刺激的反应的计算模型使得能够探索CI表现的潜在机制，而不仅仅是体内实验的能力。然而，迄今为止开发的所有ANF模型在一定程度上利用在非人类动物模型中测量的解剖/形态测量数据、生物物理特性和/或生理数据。本文比较了电刺激听觉神经（AN）在人类听者和不同哺乳动物模型中的反应特性。AN对单脉冲刺激、双脉冲刺激和脉冲串刺激的响应的性质被提出。虽然一些AN响应特性在人类收听者和动物模型之间是相似的（例如，增加AN对具有长相间间隙的单脉冲刺激的敏感性），存在一些显著差异。例如，大多数动物模型的AN通常对阴极刺激更敏感，而人类听众的AN通常对阳极刺激更敏感。此外，在动物模型和人类听者之间，神经适应的恢复速度也有很大差异。因此，动物模型的结果不能简单地翻译给人类听众。认识到人类和其他哺乳动物之间AN对电刺激的反应的差异是创建更适用于各种人类CI患者群体的ANF模型的重要步骤。
Cochlear implants (CIs) provide acoustic information to implanted patients by electrically stimulating nearby auditory nerve fibers (ANFs) which then transmit the information to higher-level neural structures for further processing and interpretation. Computational models that simulate ANF responses to CI stimuli enable the exploration of the mechanisms underlying CI performance beyond the capacity of in vivo experimentation alone. However, all ANF models developed to date utilize to some extent anatomical/morphometric data, biophysical properties and/or physiological data measured in non-human animal models. This review compares response properties of the electrically stimulated auditory nerve (AN) in human listeners and different mammalian models. Properties of AN responses to single pulse stimulation, paired-pulse stimulation, and pulse-train stimulation are presented. While some AN response properties are similar between human listeners and animal models (e.g., increased AN sensitivity to single pulse stimuli with long interphase gaps), there are some significant differences. For example, the AN of most animal models is typically more sensitive to cathodic stimulation while the AN of human listeners is generally more sensitive to anodic stimulation. Additionally, there are substantial differences in the speed of recovery from neural adaptation between animal models and human listeners. Therefore, results from animal models cannot be simply translated to human listeners. Recognizing the differences in responses of the AN to electrical stimulation between humans and other mammals is an important step for creating ANF models that are more applicable to various human CI patient populations.
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影响因子：
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作者：
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