Pattern, growth, and control.
Pattern, growth, and control.
复制标题
DOI：
10.1016/j.cell.2011.03.009
复制
发表时间：
2011-03-18
期刊：
影响因子：
64.5
通讯作者：
Lander AD
中科院分区：
文献类型：
--
作者：
Lander AD
生物学作为目标导向工程的观点在发育生物学中有着深厚的历史根源，该领域目前受益于系统生物学的思想和方法的涌入。系统生物学利用非生物学范式来解释控制的发育机制，即实现或维持预期目标的特定类型的调节。这篇评论强调了一些目前的努力，旨在阐明基本的设计原则，工程目标的鲁棒性，精度和规模，需要在发展控制的增长和模式形成。从脊椎动物和无脊椎动物的发展的例子来说明一般原则，包括积分反馈在实现设定点控制的价值;自组织行为的有用性;识别和适当处理噪声的重要性;和没有免费的午餐理论。通过对这些原则的研究，系统生物学提供了一个功能框架，以理解有机体发育的机械复杂性。
The view of biology as goal-directed engineering has deep historical roots in developmental biology, a field currently benefitting from an influx of ideas and methods from systems biology. Systems biology draws on non-biological paradigms to explain developmental mechanisms of control, the specific type of regulation that achieves or maintains a desired end. This review highlights some of the current efforts designed to elucidate basic design principles underlying the engineering objectives of robustness, precision, and scaling that are required during developmental control of growth and pattern formation. Examples from vertebrate and invertebrate development are used to illustrate general principles including the value of integral feedback in achieving set-point control; the usefulness of self-organizing behavior; the importance of recognizing and appropriately handling noise; and the No Free Lunch theory. Through the examination of such principles, systems biology offers a functional framework to make sense of the mechanistic complexity of organismal development.
登录
查看更多内容
影响因子：
64.8
作者：
Alon, U;Surette, MG;Leibler, S
通讯作者：
Leibler, S
影响因子：
9.8
作者：
Dessaud E;Ribes V;Balaskas N;Yang LL;Pierani A;Kicheva A;Novitch BG;Briscoe J;Sasai N
通讯作者：
Sasai N
影响因子：
7.3
作者：
Baena-Lopez LA;Franch-Marro X;Vincent JP
通讯作者：
Vincent JP
影响因子：
2.4
作者：
Aquino, Gerardo;Endres, Robert G.
通讯作者：
Endres, Robert G.
影响因子：
64.5
作者：
Belenkaya, TY;Han, C;Lin, XH
通讯作者：
Lin, XH