Wingless promotes proliferative growth in a gradient-independent manner.
Wingless promotes proliferative growth in a gradient-independent manner.
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DOI：
10.1126/scisignal.2000360
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发表时间：
2009-10-06
影响因子：
7.3
通讯作者：
Vincent JP
中科院分区：
文献类型：
--
作者：
Baena-Lopez LA;Franch-Marro X;Vincent JP
形态发生素形成浓度梯度，组织细胞模式并控制生长。有人认为，而不是形态发生信号的强度，它是它的分级是细胞增殖的相关调制器。根据这一观点，形态发生素在发育过程中调节生长的能力取决于它们的分级分布。在这里，我们描述了一个实验测试这个模型的无翅，在果蝇翅膀发育的关键组织者之一。最大无翅信号抑制细胞增殖。相反，我们发现，即使在没有内源性Wingless的情况下，适度和均匀量的外源性Wingless也能刺激增殖生长。除了几个细胞直径的来源，无翅是相对恒定的丰度，因此提供了一个均匀的生长促进信号。虽然形态发生信号可能与尚未表征的分级生长促进途径相结合，我们建议，形态发生信号的分级性质是不需要增殖，至少在发展中的果蝇翅膀，在主要的生长期。
Morphogens form concentration gradients that organize patterns of cells and control growth. It has been suggested that, rather than the intensity of morphogen signalling, it is its gradation that is the relevant modulator of cell proliferation. According to this view, the ability of morphogens to regulate growth during development depends on their graded distributions. Here, we describe an experimental test of this model for Wingless, one of the key organizers of wing development in Drosophila. Maximal Wingless signalling suppresses cellular proliferation. In contrast, we found that moderate and uniform amounts of exogenous Wingless, even in the absence of endogenous Wingless, stimulated proliferative growth. Beyond a few cell diameters from the source, Wingless was relatively constant in abundance and thus provided a homogeneous growth-promoting signal. Although morphogen signalling may act in combination with as yet uncharacterized graded growth-promoting pathways, we suggest that the graded nature of morphogen signalling is not required for proliferation, at least in the developing Drosophila wing, during the main period of growth.
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影响因子：
21.3
作者：
Lawrence, Peter A.;Struhl, Gary;Casal, Jose
通讯作者：
Casal, Jose
影响因子：
2.7
作者：
Adachi-Yamada, T;O'Connor, MB
通讯作者：
O'Connor, MB
影响因子：
21.3
作者：
Johnston, LA;Sanders, AL
通讯作者：
Sanders, AL
影响因子：
2.6
作者：
Resino, J;García-Bellido, A
通讯作者：
García-Bellido, A
DOI：
10.1073/pnas.93.2.640
发表时间：
1996-01-23
影响因子：
11.1
作者：
Milan, M;Campuzano, S;GarciaBellido, A
通讯作者：
GarciaBellido, A