The use of the orbitofrontal H-sulcus as a reference frame for value signals.
The use of the orbitofrontal H-sulcus as a reference frame for value signals.
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DOI：
10.1111/ejn.14590
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发表时间：
2020-05
期刊：
影响因子：
--
通讯作者：
Adamson K
中科院分区：
文献类型：
--
作者：
Troiani V;Patti MA;Adamson K
了解驱动大脑组织和功能的因素是神经科学中一个持久的问题。使用功能性磁共振成像（fMRI），基于可能驱动给定区域的组织原则（例如，初级视觉皮层中的视觉形式和初级听觉皮层中的声音频率方面）和基础细胞结构的知识。对编码更复杂信号的高级大脑区域（如眶额皮层（OFC））的组织原理还不太了解。OFC的许多功能的一个基本组成部分是计算给定对象的奖励或价值的能力。有证据表明，在眶额皮层内，对特定类别的物体（或所述物体的价值）的反应的空间位置存在变异性，并且已经提出了几个参考框架来解释这种变异性，包括对应于主要奖励与次要奖励以及积极奖励与消极奖励的轴的地形空间梯度。眶额肌中一个潜在有用的结构形态学参考框架是“H沟”，这是由内侧眶沟、外侧眶沟和横向眶沟形成的模式。在48名人类受试者中，我们使用结构形态跟踪程序定位功能激活沿着的H-沟的脸和食物刺激。我们报告的新发现，食物选择性反应一致发现内的内侧眶沟的尾部，但没有一致性的H-沟内的面部刺激的反应。这些结果表明，沟回解剖的H-沟可能是一个重要的形态学指标，有助于组织原则的OFC响应某些刺激类别，包括食物。
Understanding the factors that drive organization and function of the brain is an enduring question in neuroscience. Using functional magnetic resonance imaging (fMRI), structure and function have been mapped in primary sensory cortices based on knowledge of the organizational principles that likely drive a given region (e.g., aspects of visual form in primary visual cortex and sound frequency in primary auditory cortex) and knowledge of underlying cytoarchitecture. The organizing principles of higher-order brain areas that encode more complex signals, such as the orbitofrontal cortex (OFC), are less well understood. One fundamental component that underlies the many functions of the OFC is the ability to compute the reward or value of a given object. There is evidence of variability in the spatial location of responses to specific categories of objects (or value of said objects) within the OFC, and several reference frames have been proposed to explain this variability, including topographic spatial gradients that correspond to axes of primary versus secondary rewards and positive versus negative reinforcers. One potentially useful structural morphometric reference frame in the OFC is the “H-sulcus,” a pattern formed by medial orbital, lateral orbital and transverse orbital sulci. In 48 human subjects, we use a structural morphometric tracing procedure to localize functional activation along the H-sulcus for face and food stimuli. We report the novel finding that food-selective responses are consistently found within the caudal portion of the medial orbital sulcus, but no consistency within the H-sulcus for response to face stimuli. These results suggest that sulcogyral anatomy of the H-sulcus may be an important morphological metric that contributes to the organizing principles of the OFC response to certain stimulus categories, including food.
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