Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet.
Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet.
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DOI：
10.1016/j.metabol.2008.03.003
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发表时间：
2008-07
影响因子：
9.8
通讯作者：
Gettys, Thomas W.
中科院分区：
文献类型：
--
作者：
Stewart, Laura K.;Soileau, Jeff L.;Ribnicky, David;Wang, Zhong Q.;Raskin, Ilya;Poulev, Alexander;Majewski, Martin;Cefalu, William T.;Gettys, Thomas W.
槲皮素是一种多酚类化合物，也是人类饮食中主要的生物类黄酮，具有抗炎特性，并被认为可以提高能量消耗（EE）。我们试图确定槲皮素是否会改变体重、体成分、EE和循环炎症标志物。在6周龄时，将2组C57BL/6J小鼠（N = 80）分别饲喂高脂肪（45%卡路里脂肪）和高脂肪+槲皮素（45%卡路里脂肪+ 0.8%槲皮素）两种饲粮，分别饲喂3W或8W。用质谱法测定饮食和血浆中的槲皮素浓度。每周测量体重、成分（核磁共振）和食物摄入量。在3和8W时，通过间接量热法测量能量消耗，并在8W时测量血浆中的炎症标志物。HF饮食中槲皮素的存在并没有改变HF + Q组随时间的食物摄入，在任何时间点与HF组都没有差异。然而，循环血浆槲皮素浓度在3和8W之间下降。3W时，与HF组相比，HF + Q组的EE在白天和夜间阶段均高于HF组（P < 0.0001）；但在8W时没有发现这种差异，也没有转化为HF + Q组和HF组之间在体重或身体组成方面的显著差异。在夜间，炎症标志物（干扰素-γ、白细胞介素-1α和白细胞介素-4）浓度与HF治疗组相比显著降低（P < 0.05）。膳食中添加槲皮素会产生短暂的（3W） EE增加，而在饮食中添加8W后没有检测到。在3到8W之间，循环槲皮素的相应减少表明，代谢适应可能降低了槲皮素对EE的早期影响，并降低了其对营养分配和肥胖的总体影响。然而，所提供水平的槲皮素在8W时观察到的HF饮食动物的循环炎症标志物中是有效的。
Quercetin, a polyphenolic compound and a major bioflavonoid in the human diet, has anti-inflammatory properties and has been postulated to enhance energy expenditure (EE). We sought to determine whether quercetin alters body weight, body composition, EE, and circulating markers of inflammation. At 6 weeks (W) of age, 2 cohorts of C57BL/6J mice (N = 80) were placed on one of 2 diets for 3W or 8W: (1) high fat (HF) (45% kcal fat) or (2) high fat + quercetin (HF + Q) (45% kcal fat + 0.8% quercetin). Quercetin concentrations in the diet and plasma were evaluated using mass spectrometry. Body weight, composition (nuclear magnetic resonance), and food consumption were measured weekly. Energy expenditure was measured by indirect calorimetry at 3 and 8W, and inflammatory markers were measured in plasma obtained at 8W. The presence of quercetin in the HF diet did not alter food consumption over time in the HF + Q group and did not differ from the HF group at any time point. However, circulating plasma quercetin concentrations declined between 3 and 8W. At 3W, EE was higher during both day and night phases (P < .0001) in the HF + Q group compared with the HF group; but this difference was not detected at 8W and did not translate into significant differences between the HF + Q and HF groups with respect to body weight or body composition. During the night phase, concentrations of the inflammatory markers (interferon-γ, interleukin-1α, and interleukin-4) were significantly lower when compared with HF treatment group (P < .05). Dietary supplementation with quercetin produces transient (3W) increases in EE that are not detected after 8W on the diet. A corresponding decrease in circulating quercetin between 3 and 8W suggests that metabolic adaptation may have diminished the impact of quercetin's early effect on EE and diminished its overall effect on nutrient partitioning and adiposity. However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W.
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DOI：
10.1161/01.atv.17.11.2744
发表时间：
1997-11-01
影响因子：
8.7
作者：
Hayek, T;Fuhrman, B;Aviram, M
通讯作者：
Aviram, M
影响因子：
6.3
作者：
Camuesco, D.;Comalada, M.;Galvez, J.
通讯作者：
Galvez, J.
影响因子：
5.4
作者：
Comalada, M;Camuesco, D;Zarzuelo, A
通讯作者：
Zarzuelo, A
影响因子：
5.8
作者：
Mehta, Sachin;Farmer, John A
通讯作者：
Farmer, John A
影响因子：
2.4
作者：
Graf, BA;Milbury, PE;Blumberg, JB
通讯作者：
Blumberg, JB