Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure.
Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure.
复制标题
在高海拔暴露期间没有高原病迹象的人的可逆性大脑异常。
DOI：
10.1038/srep33596
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发表时间：
2016-09-16
影响因子：
4.6
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Fan C;Zhao Y;Yu Q;Yin W;Liu H;Lin J;Yang T;Fan M;Gesang L;Zhang J
上升到高海拔(HA)的低地居民中，很大一部分人没有表现出高原反应的迹象。他们的大脑是否真的受到了HA环境的影响以及返回低地后的持续后遗症尚不清楚。31名在青藏高原执教30天的海平面大学生在暴露前、暴露中和暴露后2个月进行了MRI扫描。测量脑体积、皮质结构和脑白质显微结构。同时检测血清神经元特异性烯醇化酶(NSE)、C反应蛋白、白介素6及神经精神行为。HA暴露30d后，灰质、白质体积和皮质表面积显著增加，皮质厚度和曲率变化较大，各向异性减小，白质束多部位弥散系数增加。HA暴露两个月后，皮质测量恢复到基础水平。然而，随着扩散系数的降低，各向异性增加。在三个时间点的测试中，行为学和血清炎症因子均无明显变化。NSE在HA期间显着降低，但在HA暴露后升高。结果表明，在HA无神经体征的人群中出现了脑肿胀，但返回低地后没有在皮质结构和神经精神功能方面留下负面后遗症。复氧改变了脑白质的微观结构。
A large proportion of lowlanders ascending to high-altitude (HA) show no signs of mountain sickness. Whether their brains have indeed suffered from HA environment and the persistent sequelae after return to lowland remain unknown. Thirty-one sea-level college students, who had a 30-day teaching on Qinghai-Tibet plateau underwent MRI scans before, during, and two months after HA exposure. Brain volume, cortical structures, and white matter microstructure were measured. Besides, serum neuron-specific enolase (NSE), C-reactive protein, and interleukin-6 and neuropsychiatric behaviors were tested. After 30-day HA exposure, the gray and white matter volumes and cortical surface areas significantly increased, with cortical thicknesses and curvatures changed in a wide spread regions; Anisotropy decreased with diffusivities increased in multiple sites of white matter tracts. Two months after HA exposure, cortical measurements returned to basal level. However, increased anisotropy with decreased diffusivities was observed. Behaviors and serum inflammatory factor did not significant changed during three time-point tests. NSE significantly decreased during HA but increased after HA exposure. Results suggest brain swelling occurred in people without neurological signs at HA, but no negative sequelae in cortical structures and neuropsychiatric functions were left after the return to lowlands. Reoxygenation changed white matter microstructure.
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DOI：
10.1073/pnas.98.4.2029
发表时间：
2001-02-13
影响因子：
11.1
作者：
Brannan, S;Liotti, M;Fox, PT
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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