Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis.
Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis.
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DOI：
10.1186/bcr1674
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Hsieh CC
中科院分区：
文献类型：
--
作者：
Savarese TM;Strohsnitter WC;Low HP;Liu Q;Baik I;Okulicz W;Chelmow DP;Lagiou P;Quesenberry PJ;Noller KL;Hsieh CC
有丝分裂原的产前水平可能会影响终身乳腺癌的风险，通过驱动干细胞增殖和增加靶细胞的数量，从而增加启动肿瘤发生的突变事件的机会。我们研究了脐带血中潜在的乳腺上皮细胞有丝分裂原（包括激素和生长因子）与造血干细胞浓度的相关性，造血干细胞浓度作为总体干细胞潜力的替代物。我们分析了289例分娩的脐带血样本。激素和生长因子水平与干细胞和祖细胞群（CD 34+细胞、CD 34 + CD 38-细胞、CD 34 +c-kit+细胞和粒细胞-巨噬细胞集落形成单位）的浓度相关。根据多元回归分析计算与有丝分裂原的每个标准差变化相关的干细胞浓度变化和相关的95%置信区间。胰岛素样生长因子-1（IGF-1）的脐带血血浆水平与所有检查的造血干细胞和祖细胞浓度密切相关（IGF-1的一个标准差增加与干细胞/祖细胞浓度增加15-19%相关，所有P < 0.02）。雌三醇和胰岛素样生长因子结合蛋白-3水平与这些细胞群中的一些呈正相关。性成熟结合球蛋白水平与这些干/祖细胞池呈负相关。这些关系在高加索人和西班牙裔人中更强，在亚裔美国人和非洲裔美国人中较弱或不存在。我们的数据支持子宫内有丝分裂原可能驱动干细胞群体扩增的概念。与IGF-1和雌激素的相关性值得注意，因为两者对乳腺发育至关重要。
Prenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential. We analyzed cord blood samples from 289 deliveries. Levels of hormones and growth factors were correlated with concentrations of stem cell and progenitor populations (CD34+ cells, CD34+CD38- cells, CD34+c-kit+ cells, and granulocyte–macrophage colony-forming units). Changes in stem cell concentration associated with each standard deviation change in mitogens and the associated 95% confidence intervals were calculated from multiple regression analysis. Cord blood plasma levels of insulin-like growth factor-1 (IGF-1) were strongly correlated with all the hematopoietic stem and progenitor concentrations examined (one standard-deviation increase in IGF-1 being associated with a 15–19% increase in stem/progenitor concentrations, all P < 0.02). Estriol and insulin-like growth factor binding protein-3 levels were positively and significantly correlated with some of these cell populations. Sex hormone-binding globulin levels were negatively correlated with these stem/progenitor pools. These relationships were stronger in Caucasians and Hispanics and were weaker or not present in Asian-Americans and African-Americans. Our data support the concept that in utero mitogens may drive the expansion of stem cell populations. The correlations with IGF-1 and estrogen are noteworthy, as both are crucial for mammary gland development.
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影响因子：
10.5
作者：
Gudjonsson, T;Villadsen, R;Petersen, OW
通讯作者：
Petersen, OW
影响因子：
10.3
作者：
Ekbom, A;Hsieh, CC;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
105.7
作者：
Ekbom, A;Hsieh, CC;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
8.8
作者：
Andersson, SW;Bengtsson, C;Hulthén, L
通讯作者：
Hulthén, L
DOI：
10.1093/jnci/87.21.1622
发表时间：
1995-11-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
BYRNE, C;SCHAIRER, C;HAILE, R
通讯作者：
HAILE, R