Development of the ovarian follicular epithelium
Development of the ovarian follicular epithelium
复制标题
卵巢滤泡上皮的发育
DOI：
10.1016/s0303-7207(99)00087-8
复制
发表时间：
1999
影响因子：
4.1
通讯作者：
H. Irving
中科院分区：
文献类型：
--
作者：
R. Rodgers;T. Lavranos;I. L. V. Wezel;H. Irving
关于卵巢卵泡发育的内分泌调控，我们已经了解了很多，但究竟是哪些分子和细胞过程参与了卵泡生长发育的调控，是目前研究人员面临的一个关键问题。卵巢卵泡的生长和发育发生在出生后和整个成年生活中。在这篇综述中，我们主要关注滤泡上皮（颗粒膜）及其基底层。我们讨论了颗粒细胞如何从干细胞群体中产生，然后在分化之前进入不同的谱系的模型。介绍了中央发育阶段的上皮结构，并讨论了卵泡生长对颗粒细胞行为的影响。最后，我们讨论了卵泡发育过程中卵泡基底层组成变化的证据。如果颗粒细胞的行为发生变化，或者基底层的通透性发生变化，这是可以预料到的。很明显，滤泡上皮与体内其他上皮有相似之处，但它更具动态性，因为在卵泡发育过程中会发生明显的变化。这一基本信息将对未来人类和动物生殖技术的发展具有重要意义，并可能对了解女性多囊卵巢综合征具有重要意义。
A lot is known about the endocrine control of the development of ovarian follicles, but a key question now facing researchers is which molecular and cellular processes take part in control of follicular growth and development. The growth and development of ovarian follicles occurs postnatally and throughout adult life. In this review, we focus on the follicular epithelium (membrana granulosa) and its basal lamina. We discuss a model of how granulosa cells arise from a population of stem cells and then enter different lineages before differentiation. The structure of the epithelium at the antral stage of development is presented, and the effects that follicle growth has on the behavior of the granulosa cells are discussed. Finally, we discuss the evidence that during follicle development the follicular basal lamina changes in composition. This would be expected if the behavior of the granulosa cells changes, or if the permeability of the basal lamina changes. It will be evident that the follicular epithelium has similarities to other epithelia in the body, but that it is more dynamic, as gross changes occur during the course of follicle development. This basic information will be important for the development of future reproductive technologies in both humans and animals, and possibly for understanding polycystic ovarian syndrome in women.
影响因子：
56.9
作者：
KIM, NW;PIATYSZEK, MA;SHAY, JW
通讯作者：
SHAY, JW
影响因子：
2.7
作者：
SALUSTRI, A;YANAGISHITA, M;HASCALL, VC
通讯作者：
HASCALL, VC
通过免疫细胞化学研究大鼠卵巢催乳素受体和催乳素的细胞内定位。
影响因子：
4.8
作者：
Dunaif,AE;Zimmerman,EA;Friesen,HG;Frantz,AG
通讯作者：
Frantz,AG