Adolescent overeating and binge eating behavior in relation to subsequent cardiometabolic risk outcomes: a prospective cohort study.
Adolescent overeating and binge eating behavior in relation to subsequent cardiometabolic risk outcomes: a prospective cohort study.
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DOI：
10.1186/s40337-022-00660-4
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发表时间：
2022-09-13
影响因子：
4.1
通讯作者：
Oken E
中科院分区：
文献类型：
--
作者：
Zhou JC;Rifas-Shiman SL;Haines J;Jones K;Oken E
暴饮暴食障碍与肥胖和代谢综合征双向相关。不太清楚的是，暴饮暴食或暴饮暴食是否也能预测代谢风险，如果是的话，这些联系是否完全可归因于体重增加。这项研究的目的是检查青春期暴饮暴食行为与心脏代谢风险标记物的纵向联系。Viva项目研究研究中的青少年(n = 619)自我报告了青春期早期的暴饮暴食行为(中位数12.9岁，“基线”)。在青春期晚期(中位数17.4年)，我们评估了肥胖和血压的结果，并在一组参与者(n = 270-424)中，评估了血脂异常、胰岛素抵抗、肝功能障碍、炎症和脂肪因子稳态的生物标志物。我们进行了多变量线性回归分析，调整了社会人口学和产前肥胖暴露，并对基线体重指数(BMI)z得分进行了调整。在基线时，58名(9%)参与者报告了暴饮暴食的行为，其中24人(41%)有暴饮暴食的行为(例如，暴饮暴食伴随着失控)。在调整后的模型中，暴饮暴食的青少年在5年后的随访 ~ 中有更高的肥胖率(例如，%体脂4.03；95%可信区间(CI)1.76，6.31)比那些没有报告暴饮暴食行为的青少年；对基线体重指数z分数的额外调整通常会减弱除%体脂(2.95；95%CI 1.03，4.87)之外的相关性。暴饮暴食行为也与更高的炎症和更严重的脂肪因子功能障碍相关，即使在调整基线体重指数z得分后，与IL-6(对数转换的β = 0.42pg/mL；95%可信区间0.12，0.73)和脂联素(对数转换的β = −0.28ug/mL；95%可信区间 − 0.47， − 0.08)仍然呈正相关。暴饮暴食行为与其他结果并不一致。与那些没有暴饮暴食的青少年相比，有暴饮暴食行为的青少年通常有最大的肥胖症(例如，%体脂5.00；95%可信区间1.74，8.25)。与不支持这些行为的青少年相比，报告暴饮暴食行为的青少年肥胖程度更高，炎症和脂肪因子特征更差，但在其他结果上没有差异。较高的基线BMI z分数只能部分解释这些相关性。这些差异可能预示着未来患心血管疾病的风险增加。网上版载有补充材料，可在10.1186/s40337-022-00660-4查阅。我们研究了暴饮暴食和暴饮暴食行为风险标记物与未来心脏病和糖尿病的关系。项目研究中的青少年(n = 619)在青春期早期(~ 13岁，“基线”)完成的问卷调查中自我报告了暴饮暴食的行为。在青春期晚期(~ 17岁，“随访”)，我们收集了体脂和血压的研究指标，并在参与者的子组中收集了血液中胆固醇、脂肪相关激素、肝功能障碍和炎症的水平。我们应用分析方法来调整社会人口统计学，并更好地理解基线权重如何解释这种关联。在基线时，58名(9%)参与者报告了暴饮暴食的行为，其中24人(41%)有暴饮暴食的行为(例如，暴饮暴食伴随着失控的感觉)。我们发现，与那些没有报告暴饮暴食的青少年相比，报告暴饮暴食的青少年后来的体脂较高，而炎症和脂肪激素浓度较低。暴饮暴食的人也有更高的基线体重，这一事实只是部分解释了这些联系。在有或没有暴饮暴食的人中，青春期后期心脏代谢风险的其他标志没有区别。总体而言，我们的研究表明，暴饮暴食和暴饮暴食的行为与心脏病和糖尿病风险的一些较高标志有关。网上版载有补充材料，可在10.1186/s40337-022-00660-4查阅。
Binge eating disorder is bidirectionally associated with obesity and with metabolic syndrome. It is less clear whether overeating and binge eating, or overeating with loss of control, also predicts metabolic risk, and if so, whether these associations are solely attributable to greater weight. The goal of this study was to examine longitudinal associations of overeating and binge eating behavior with cardiometabolic risk markers in adolescence. Adolescents (n = 619) in the Project Viva research study self-reported overeating and binge eating behavior in early adolescence (median 12.9 years, “baseline”). In late adolescence (median 17.4 years, “follow-up”), we assessed outcomes of adiposity and blood pressure, and in a subset of participants (n = 270–424), biomarkers of dyslipidemia, insulin resistance, liver dysfunction, inflammation, and adipokine homeostasis. We conducted multivariable linear regression analyses adjusted for socio-demographics and prenatal obesogenic exposures, and additionally for baseline body mass index (BMI) z-score. At baseline, 58 (9%) participants reported overeating behavior, and of those, 24 (41%) had binge eating behavior (e.g., overeating accompanied by loss of control). In adjusted models, adolescents with overeating had higher adiposity at follow-up ~ 5 years later (e.g., % body fat 4.03; 95% confidence interval (CI) 1.76, 6.31) than those not reporting overeating behavior; additional adjustment for baseline BMI z-score attenuated associations generally except for % body fat (2.95; 95% CI 1.03, 4.87). Overeating behavior was also associated with higher inflammation and greater adipokine dysfunction, remaining positively associated with interleukin-6 (IL-6) (log-transformed β = 0.42 pg/mL; 95% CI 0.12, 0.73) and negatively with adiponectin (log-transformed β = −0.28 ug/mL; 95% CI − 0.47, − 0.08) even after adjusting for baseline BMI z-score. Overeating behavior was not consistently associated with other outcomes. Adolescents reporting binge eating behavior generally had the greatest adiposity, (e.g., % body fat 5.00; 95% CI 1.74, 8.25) as compared to those without overeating. Adolescents reporting overeating and binge eating behavior had higher adiposity and poorer inflammatory and adipokine profiles, but no difference in other outcomes, than adolescents who did not endorse these behaviors. These associations were only partially accounted for by higher baseline BMI z-score. These differences may signal increased risk for future cardiovascular disease. The online version contains supplementary material available at 10.1186/s40337-022-00660-4. We examined associations of overeating and binge eating behavior risk markers for future heart disease and diabetes. Adolescents (n = 619) in the Project Viva research study self-reported overeating and binge eating behavior on questionnaires completed in early adolescence (~ 13 years, “baseline”). In late adolescence (~ 17 years, “follow-up”), we collected research measures of body fat and blood pressure, and in a subset of participants, blood levels of cholesterol, fat-related hormones, liver dysfunction, and inflammation. We applied analytic methods to adjust for socio-demographics and to better understand how baseline weight could explain the associations. At baseline, 58 (9%) participants reported overeating behavior, and of those, 24 (41%) had binge eating behavior (e.g., overeating behavior accompanied by feeling loss of control). We found that adolescents reporting overeating behavior had higher later body fat and poorer inflammatory and fat hormone concentrations than those who did not report overeating. These associations were only partially explained by the fact that those with overeating also had higher baseline weight. Other markers of cardiometabolic risk in late adolescence were not different among those with or without overeating. Overall, our study suggests that overeating and binge eating behavior are associated with some higher markers of heart disease and diabetes risk. The online version contains supplementary material available at 10.1186/s40337-022-00660-4.
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影响因子：
6.9
作者：
Klump, K. L.;Culbert, K. M.;Slane, J. D.;Burt, S. A.;Sisk, C. L.;Nigg, J. T.
通讯作者：
Nigg, J. T.
影响因子：
4.9
作者：
Miller, R.;Tanofsky-Kraff, M.;Yanovski, J. A.
通讯作者：
Yanovski, J. A.
影响因子：
4.2
作者：
Stice, E;Presnell, K;Spangler, D
通讯作者：
Spangler, D
影响因子：
5.4
作者：
Carrero, Juan Jesus;Franko, Mikael Andersson;Jernberg, Tomas
通讯作者：
Jernberg, Tomas
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F