Early-onset sepsis in term infants admitted to neonatal intensive care units (2011-2016).
Early-onset sepsis in term infants admitted to neonatal intensive care units (2011-2016).
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DOI：
10.1038/s41372-020-00860-3
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Greenberg RG
中科院分区：
文献类型：
--
作者：
Polcwiartek LB;Smith PB;Benjamin DK;Zimmerman K;Love A;Tiu L;Murray S;Kang P;Ebbesen F;Hagstrøm S;Clark RH;Greenberg RG
调查新生儿重症监护病房（NICUs）足月婴儿培养的特征，评估早发性脓毒症（EOS），引起EOS的微生物频率，以及与EOS相关的因素。采用队列设计，我们选取了326例新生儿重症监护病房（2011-2016）中通过血液、脑脊液或尿液培养评估EOS的足月婴儿。使用多变量逻辑回归，我们调查了EOS与人口统计学特征之间的关系。在142,410名婴儿中，1197名（0.8%）患有EOS，最常见的是由B群链球菌（GBS; 40.6%）引起的。较低的EOS风险与低Apgar评分、剖宫产、小胎龄、产前抗生素暴露、阳性或未知的母体GBS筛查结果相关。增加的风险与胎膜破裂时间延长、母亲年龄<19岁、血管加压剂治疗和呼吸机支持有关。GBS是最常见的EOS原因。早期危险因素的识别有助于新生儿重症监护病房足月儿的日常管理。
Investigate characteristics of term infants culture-evaluated for early-onset sepsis (EOS) in neonatal intensive care units (NICUs), frequencies of organisms causing EOS, and factors associated with EOS. Using a cohort design, we identified term infants evaluated for EOS with blood, cerebrospinal fluid, or urine cultures in 326 NICUs (2011–2016). Using multivariable logistic regression, we investigated the association between EOS and demographic characteristics. Of 142,410 infants, 1197 (0.8%) had EOS, most commonly caused by group B Streptococcus (GBS; 40.6%). Lower EOS risk was associated with low Apgar score, Cesarean delivery, small for gestational age, prenatal antibiotic exposure, and positive or unknown maternal GBS screening result. Increased risk was associated with prolonged rupture of membranes, maternal age <19 years, vasopressor treatment, and ventilator support. GBS was the most frequent cause of EOS. Early risk factor recognition may help daily management of term infants in NICUs.
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影响因子：
5.8
作者：
Nielsen, Maryke;Sheikh, Naveed;Drew, Richard J.
通讯作者：
Drew, Richard J.
DOI：
10.1097/inf.0b013e3181acf6bd
发表时间：
2009-12
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Cohen-Wolkowiez M;Moran C;Benjamin DK;Cotten CM;Clark RH;Benjamin DK Jr;Smith PB
通讯作者：
Smith PB
影响因子：
26.1
作者：
Kuzniewicz, Michael W.;Puopolo, Karen M.;Escobar, Gabriel J.
通讯作者：
Escobar, Gabriel J.
影响因子：
158.5
作者：
Van Dyke, Melissa K.;Phares, Christina R.;Schrag, Stephanie J.
通讯作者：
Schrag, Stephanie J.
影响因子：
2.1
作者：
Lin, Chia-Ying;Hsu, Chyong-Hsin;Chen, Chie-Pein
通讯作者：
Chen, Chie-Pein