A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines.
A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines.
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关于肠道菌群与Covid-19疫苗之间相互作用的全面观点。
DOI：
10.1080/19490976.2023.2233146
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发表时间：
2023-01
期刊：
影响因子：
12.2
通讯作者：
中科院分区：
文献类型：
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作者：
COVID-19疫苗的有效性在个体和人群之间存在差异，其原因仍不完全清楚。最近的临床研究和动物模型表明，肠道微生物群可能会影响疫苗的免疫原性，从而影响其有效性。这表明肠道微生物群和COVID-19疫苗之间存在双向关系，微生物群的不同成分可以增强或降低疫苗的效力。为了制止COVID-19大流行的传播，现在比以往任何时候都更需要能够产生强大和长期免疫力的疫苗，而了解肠道微生物群在这一过程中的作用至关重要。相反，COVID-19疫苗对肠道微生物群也有显著影响，减少了微生物总数和存在的物种种类。在这篇综述中，我们分析了表明肠道微生物群与COVID-19疫苗有效性之间相互作用的证据，考虑了可能导致这种联系的免疫学机制，并探索了使用肠道微生物群为重点的干预措施来提高COVID-19疫苗有效性的可能性。
The efficacy of COVID-19 vaccines varies between individuals and populations, and the reasons for this are still not fully understood. Recent clinical studies and animal models have indicated that the gut microbiota may influence the immunogenicity of the vaccine and, thus, its effectiveness. This suggests that there is a bidirectional relationship between the gut microbiota and the COVID-19 vaccine, with the varying components of the microbiota either enhancing or reducing the vaccine’s efficacy. To put an end to the spread of the COVID-19 pandemic, the necessity of vaccines that create powerful and long-term immunity is now more important than ever, and understanding the role of the gut microbiota in this process is essential. Conversely, COVID-19 vaccines also have a significant effect on the gut microbiota, decreasing its total number of organisms and the variety of species present. In this Review, we analyze the evidence that suggesting an interaction between the gut microbiota and COVID-19 vaccine effectiveness, consider the immunological mechanisms that may be responsible for this connection, and explore the possibility of using gut microbiota-focused interventions to improve the efficacy of COVID-19 vaccines.
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评估 2020 年 1 月 1 日至 2022 年 7 月 31 日期间美国各州的 COVID-19 大流行政策和行为及其经济和教育权衡：观察分析。
DOI：
10.1016/s0140-6736(23)00461-0
发表时间：
2023-04-22
期刊：
Lancet (London, England)
影响因子：
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作者：
通讯作者：
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影响因子：
2.7
作者：
Das, Saibal;Tiwari, Sayali;Xaviar, Suja
通讯作者：
Xaviar, Suja
影响因子：
7.3
作者：
Wolfe, Alex E.;Markey, Kate A.
通讯作者：
Markey, Kate A.
影响因子：
3.7
作者：
Bajinka, Ousman;Tan, Yurong;Darboe, Alansana;Ighaede-Edwards, Isabella Gloria;Abdelhalim, Khalid A. A.
通讯作者：
Abdelhalim, Khalid A. A.
影响因子：
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作者：
Colton, Hayley;Hodgson, David;Collini, Paul J
通讯作者：
Collini, Paul J