The gut microbiota pathway mechanisms of diabetes.
The gut microbiota pathway mechanisms of diabetes.
复制标题
糖尿病的肠道微生物群途径机制。
DOI：
10.1186/s13568-023-01520-3
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发表时间：
2023-02-08
期刊：
影响因子：
3.7
通讯作者：
Abdelhalim, Khalid A. A.
中科院分区：
文献类型：
--
作者：
Bajinka, Ousman;Tan, Yurong;Darboe, Alansana;Ighaede-Edwards, Isabella Gloria;Abdelhalim, Khalid A. A.
关键词：
在通过增加能量来提及代谢紊乱时，肠道菌群结构失调的贡献至关重要。重要的是要了解肠道微生物群诱导代谢疾病机制和炎症。因此，必须深入了解影响疾病结果的所有慢性亚临床炎症的状态。但从不断涌现的研究来看，此类研究的结果仍存在不一致的情况。在充分利用研究结果不一致的原因的同时，本次综述旨在明确阐明肠道微生物群与糖尿病之间的不一致。它认为肠道病毒组改变和糖尿病以及肠道细菌组肠道病毒组改变和糖尿病是混杂因素。该综述进一步解释了一些研究设计策略，这些策略将自发地消除任何潜在的混杂因素，从而产生更加基于证据的糖尿病肠道微生物群药物。脂多糖（LPS）促炎、代谢性内毒素血症和饮食/肠道微生物群胰岛素抵抗以及肠道微生物群诱导的低度全身炎症可以触发胰岛素抵抗中的促炎细胞因子，从而导致糖尿病。虽然饮食会影响肠道微生物群，但其后果主要是循环系统中促炎细胞因子的持续高水平。最近，膳食天然产品已被证明具有抗糖尿病作用。白藜芦醇对肠道的影响显示出改善血脂、抗炎特性，并改善内毒素血症、紧密连接和葡萄糖耐受不良。
The contribution of dysbiotic gut microbiota configuration is essential when making reference to the metabolic disorders by increasing energy. It is important to understand that the gut microbiota induced metabolic disease mechanisms and inflammations. Thus it is imperative to have an insight into the state of all chronic subclinical inflammations influencing disease outcomes. However, from the emerging studies, there still exist inconsistencies in the findings of such studies. While making the best out of the reasons for inconsistencies of the findings, this review is designed to make a clear spell out as to the inconsistence of gut microbiota with respect to diabetes. It considered gut-virome alterations and diabetes and gut-bacteriome-gut-virome-alterations and diabetes as confounding factors. The review further explained some study design strategies that will spontaneously eliminate any potential confounding factors to lead to a more evidence based diabetic-gut microbiota medicine. Lipopolysaccharide (LPS) pro-inflammatory, metabolic endotoxemia and diet/gut microbiota insulin-resistance and low-grade systemic inflammation induced by gut microbiota can trigger pro-inflammatory cytokines in insulin-resistance, consequently, leading to the diabetic condition. While diet influences the gut microbiota, the consequences are mainly the constant high levels of pro-inflammatory cytokines in the circulatory system. Of recent, dietary natural products have been shown to be anti-diabetic. The effects of resveratrol on the gut showed an improved lipid profile, anti-inflammatory properties and ameliorated the endotoxemia, tight junction and glucose intolerance.
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