The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI.
The Effect of Degeneration on Internal Strains and the Mechanism of Failure in Human Intervertebral Discs Analyzed Using Digital Volume Correlation (DVC) and Ultra-High Field MRI.
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应用数字体积相关(DVC)和超高场MRI分析退变对椎间盘内部应变的影响及破坏机制。
DOI：
10.3389/fbioe.2020.610907
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发表时间：
2020
影响因子：
5.7
通讯作者：
Newell N
中科院分区：
文献类型：
--
作者：
Tavana S;Masouros SD;Baxan N;Freedman BA;Hansen UN;Newell N
椎间盘（IVD）在吸收和传递脊柱内的负荷方面起主要作用。变性改变了IVD的结构完整性并引起疼痛，尤其是在腰椎区域。本研究的目的是使用数字体积相关（DVC）和9.4 T磁共振成像（MRI），在纯轴向压缩下，非侵入性地研究退化对人3D腰椎IVD应变（n = 8）的影响和脊柱失效的机制（n = 10）。与非退化IVD相比，退化IVD具有更高（p < 0.05）的轴向应变（高58%）、最大3D压缩应变（高43%）和最大3D剪切应变（高41%），特别是在外侧和后环中。在退化和非退化IVD，峰值拉伸和剪切应变观察接近终板。在所有退化的IVD中观察到内环向内隆起，导致向内隆起部位的AF压缩、拉伸和剪切应变增加，这可能使其易于发生周向撕裂（分层）。终板是脊柱在纯轴向压缩时的“薄弱环节”，人类椎体骨折的机制与椎间盘退变有关。在非退化的IVD的失败的位置接近终板的质心，而在退化的IVD，他们在周边地区。这些发现推进了对IVD退行性变期间机械变化的了解，这有助于降低损伤风险、优化治疗并改进脊柱植入物设计。此外，这些新数据可用于验证计算模型。
The intervertebral disc (IVD) plays a main role in absorbing and transmitting loads within the spinal column. Degeneration alters the structural integrity of the IVDs and causes pain, especially in the lumbar region. The objective of this study was to investigate non-invasively the effect of degeneration on human 3D lumbar IVD strains (n = 8) and the mechanism of spinal failure (n = 10) under pure axial compression using digital volume correlation (DVC) and 9.4 Tesla magnetic resonance imaging (MRI). Degenerate IVDs had higher (p < 0.05) axial strains (58% higher), maximum 3D compressive strains (43% higher), and maximum 3D shear strains (41% higher), in comparison to the non-degenerate IVDs, particularly in the lateral and posterior annulus. In both degenerate and non-degenerate IVDs, peak tensile and shear strains were observed close to the endplates. Inward bulging of the inner annulus was observed in all degenerate IVDs causing an increase in the AF compressive, tensile, and shear strains at the site of inward bulge, which may predispose it to circumferential tears (delamination). The endplate is the spine's “weak link” in pure axial compression, and the mechanism of human vertebral fracture is associated with disc degeneration. In non-degenerate IVDs the locations of failure were close to the endplate centroid, whereas in degenerate IVDs they were in peripheral regions. These findings advance the state of knowledge on mechanical changes during degeneration of the IVD, which help reduce the risk of injury, optimize treatments, and improve spinal implant designs. Additionally, these new data can be used to validate computational models.
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影响因子：
2.8
作者：
Jackman, Timothy M.;Hussein, Amira I.;Morgan, Elise F.
通讯作者：
Morgan, Elise F.
影响因子：
168.9
作者：
Freemont, AJ;Peacock, TE;Jayson, MIV
通讯作者：
Jayson, MIV
影响因子：
2
作者：
Disney, C. M.;Lee, P. D.;Bay, B. K.
通讯作者：
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影响因子：
3
作者：
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通讯作者：
Mow, VC
影响因子：
28.1
作者：
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通讯作者：
Mauck, Robert L.