Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract.
Modelling the co-occurrence of Streptococcus pneumoniae with other bacterial and viral pathogens in the upper respiratory tract.
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DOI：
10.1016/j.vaccine.2006.09.020
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发表时间：
2007-03-22
期刊：
影响因子：
5.5
通讯作者：
Kalgoorlie Otitis Media Research Project Team
中科院分区：
文献类型：
--
作者：
Jacoby P;Watson K;Bowman J;Taylor A;Riley TV;Smith DW;Lehmann D;Kalgoorlie Otitis Media Research Project Team
中耳炎(OM)是所有儿童的主要负担，特别是对澳大利亚土著儿童。肺炎链球菌、卡他莫拉菌、流感嗜血杆菌和病毒(包括鼻病毒和腺病毒)与OM有关。我们调查了西澳大利亚州79名土著儿童的435份样本和88名非土著儿童的570份样本中的鼻咽微生物相互作用。我们描述了一种适用于纵向数据分析的多变量随机效应模型，该模型能够识别成对病原体之间的两个独立的相关性水平。在微生物水平上，鼻病毒感染与肺炎链球菌、流感嗜血杆菌和卡他支原体的携带以及腺病毒与卡他支原体的携带呈正相关。一般来说，细菌病原菌在寄主和微生物水平上都是正相关的。微生物水平上的病毒与细菌的积极关联支持了先前的发现，即病毒感染可能使个人更容易携带细菌。病毒疫苗可能有助于减轻细菌性疾病的负担。
Otitis media (OM) is a major burden for all children, particularly for Australian Aboriginal children. Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae and viruses (including rhinovirus and adenovirus) are associated with OM. We investigated nasopharyngeal microbial interactions in 435 samples collected from 79 Aboriginal and 570 samples from 88 non-Aboriginal children in Western Australia. We describe a multivariate random effects model appropriate for analysis of longitudinal data, which enables the identification of two independent levels of correlation between pairs of pathogens. At the microbe level, rhinovirus infection was positively correlated with carriage of S. pneumoniae, H. influenzae and M. catarrhalis, and adenovirus with M. catarrhalis. Generally, there were positive associations between bacterial pathogens at both the host and microbe level. Positive viral–bacterial associations at the microbe level support previous findings indicating that viral infection can predispose an individual to bacterial carriage. Viral vaccines may assist in reducing the burden of bacterial disease.
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DOI：
10.1016/s1473-3099(06)70466-2
发表时间：
2006-05
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Brundage JF
通讯作者：
Brundage JF
影响因子：
6.7
作者：
Lysenko ES;Ratner AJ;Nelson AL;Weiser JN
通讯作者：
Weiser JN
影响因子：
11.8
作者：
Regev-Yochay, G;Raz, M;Rubinstein, E
通讯作者：
Rubinstein, E
影响因子：
5.4
作者：
Avadhanula, V;Rodriguez, CA;Adderson, EE
通讯作者：
Adderson, EE
影响因子：
6.4
作者：
Peltola, VT;Murti, KG;McCullers, JA
通讯作者：
McCullers, JA