A force-generating machinery maintains the spindle at the cell center during mitosis.
A force-generating machinery maintains the spindle at the cell center during mitosis.
复制标题
DOI：
10.1126/science.aad9745
复制
发表时间：
2016-05-27
期刊：
影响因子：
--
通讯作者：
Howard J
中科院分区：
文献类型：
--
作者：
Garzon-Coral C;Fantana HA;Howard J
The position and orientation of the mitotic spindle is precisely regulated to ensure the accurate partition of the cytoplasm between daughter cells and the correct localization of the daughters within growing tissue. Using magnetic tweezers to perturb the position of the spindle in intact cells, we discovered a force-generating machinery that maintains the spindle at the cell center during metaphase and anaphase in one- and two-cell C. elegans embryos. The forces increase with the number of microtubules and are larger in smaller cells. The machinery is rigid enough to suppress thermal fluctuations to ensure precise localization of the mitotic spindle, yet compliant enough to allow molecular force generators to fine-tune the position of the mitotic spindle to facilitate asymmetric division.
登录
查看更多内容
影响因子：
11.8
作者：
Srayko, M;Kaya, A;Hyman, AA
通讯作者：
Hyman, AA
DOI：
10.1083/jcb.97.2.542
发表时间：
1983-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Nicklas RB
通讯作者：
Nicklas RB
影响因子：
6.1
作者：
McIntosh, J. Richard;Molodtsov, Maxim I.;Ataullakhanov, Fazly I.
通讯作者：
Ataullakhanov, Fazly I.
影响因子：
2
作者：
Howard, J
通讯作者：
Howard, J
影响因子：
56.9
作者：
Grill, SW;Howard, J;Hyman, A
通讯作者：
Hyman, A