Enabling skin vaccination using new delivery technologies.
Enabling skin vaccination using new delivery technologies.
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DOI：
10.1007/s13346-010-0005-z
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发表时间：
2011-02-01
影响因子：
5.4
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Kim, Yeu-Chun;Prausnitz, Mark R.
众所周知，皮肤是接种疫苗的高度免疫原性部位，但临床使用的疫苗很少针对皮肤，这主要是因为传统的皮内注射困难且不可靠。现在，许多新的或新适应的递送技术已经被证明可以通过非侵入性或微创性方法将疫苗注射到皮肤上。非侵入性方法包括高速粉末和液体喷射注射，以及结合皮肤磨损、热消融、超声、电穿孔和化学增强剂的扩散贴片。微创方法一般以小针为基础，包括实心微针贴片、空心微针注射、纹身枪等。这些先进的递送技术的引入可以使皮肤成为简单、可靠的疫苗接种地点，从而提高疫苗的免疫原性，并提供物流优势，以提高疫苗接种的速度和覆盖率。
The skin is known to be a highly immunogenic site for vaccination, but few vaccines in clinical use target skin largely because conventional intradermal injection is difficult and unreliable to perform. Now, a number of new or newly adapted delivery technologies have been shown to administer vaccine to the skin either by non-invasive or minimally invasive methods. Non-invasive methods include high-velocity powder and liquid jet injection, as well as diffusion-based patches in combination with skin abrasion, thermal ablation, ultrasound, electroporation, and chemical enhancers. Minimally invasive methods are generally based on small needles, including solid microneedle patches, hollow microneedle injections, and tattoo guns. The introduction of these advanced delivery technologies can make the skin a site for simple, reliable vaccination that increases vaccine immunogenicity and offers logistical advantages to improve the speed and coverage of vaccination.
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