Transcranial Doppler ultrasound: technique and application.

Transcranial Doppler ultrasound: technique and application.
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DOI:
10.1055/s-0032-1331812
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发表时间:
2012-09
影响因子:
2.7
通讯作者:
Sorond F
Sorond F
中科院分区:
医学3区
文献类型:
--
作者:
Purkayastha S;Sorond F

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经颅多普勒(TCD)超声提供了快速,无创,实时测量脑血管功能。TCD可用于测量大脑基底动脉中的流速,以评估流量的相对变化,诊断局灶性血管狭窄,或检测这些动脉内的栓塞信号。TCD还可用于通过测量血流对血压变化(脑自动调节)、潮气末CO2变化(脑血管反应性)或认知和运动激活(神经血管耦合或功能性充血)的反应来评估特定血管区域的生理健康。TCD在临床诊断许多脑血管疾病如急性缺血性中风、血管痉挛、蛛网膜下腔出血、镰状细胞病以及其他疾病如脑死亡中已建立实用性。这种成像模式的临床适应症和研究应用不断扩大。本文综述了经颅多普勒的基本原理和临床应用,并概述了经颅多普勒的一些研究应用。
Transcranial Doppler (TCD) ultrasound provides rapid, noninvasive, real-time measures of cerebrovascular function. TCD can be used to measure flow velocity in the basal arteries of the brain to assess relative changes in flow, diagnose focal vascular stenosis, or to detect embolic signals within these arteries. TCD can also be used to assess the physiologic health of a particular vascular territory by measuring blood flow responses to changes in blood pressure (cerebral autoregulation), changes in end-tidal CO2 (cerebral vasoreactivity), or cognitive and motor activation (neurovascular coupling or functional hyperemia). TCD has established utility in the clinical diagnosis of a number of cerebrovascular disorders such as acute ischemic stroke, vasospasm, subarachnoid hemorrhage, sickle cell disease, as well as other conditions such as brain death. Clinical indication and research applications for this mode of imaging continue to expand. In this review, the authors summarize the basic principles and clinical utility of TCD and provide an overview of a few TCD research applications.
DOI: 10.1161/01.str.21.11.1579
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