Rotated spiral RARE for high spatial and temporal resolution volumetric arterial spin labeling acquisition.
Rotated spiral RARE for high spatial and temporal resolution volumetric arterial spin labeling acquisition.
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DOI：
10.1016/j.neuroimage.2020.117371
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发表时间：
2020-12
期刊：
影响因子：
5.7
通讯作者：
Alsop, David C.
中科院分区：
文献类型：
--
作者：
Munsch, Fanny;Taso, Manuel;Zhao, Li;Lebel, R. Marc;Guidon, Arnaud;Detre, John A.;Alsop, David C.
动脉自旋标记(ASL)MRI可以提供对时间平均血流量及其时间波动敏感的定量图像。ASL的3D图像采集是可取的，因为它们更容易与背景抑制兼容以减少噪声，可以减少信号损失和失真，并在整个大脑中提供均匀的血流敏感性。然而，获得最大时间分辨率的单次3D采集通常涉及通过并行成像进行模糊或噪声放大而导致的图像质量下降。在这里，我们报告了一种新的方法，通过伪黄金角旋转和压缩传感重建来加速常用的螺旋3D图像采集，而不会对时间平均血流图像产生任何退化。28名健康志愿者在3T使用背景抑制的不平衡伪连续ASL结合伪金角度螺旋堆叠3D稀有读数进行成像。通过3D非均匀快速傅立叶变换(NuFFT)重建全采样的灌注加权体积，然后对32个单独的通道进行平方和合并。评估线圈的灵敏度，然后使用L1小波压缩感觉重建重建39个单次激发体积。最后，在BOLD信号存在低信噪比和易感性伪影的区域进行了大脑连通性分析。用非参考3D模糊度量评估的全时平均血流的图像质量与传统的交错采集相当。加速提供的时间分辨率使得即使在杏仁核和额叶下部等较低的区域也能够识别和量化静息状态网络，在这些区域，易感性伪影会降低传统的静息状态fMRI采集。这种方法可以在任何使用ASL进行静息血流的研究或临床方案中免费提供血流调节和静息状态网络的测量。
Arterial Spin Labeling (ASL) MRI can provide quantitative images that are sensitive to both time averaged blood flow and its temporal fluctuations. 3D image acquisitions for ASL are desirable because they are more readily compatible with background suppression to reduce noise, can reduce signal loss and distortion, and provide uniform flow sensitivity across the brain. However, single-shot 3D acquisition for maximal temporal resolution typically involves degradation of image quality through blurring or noise amplification by parallel imaging. Here, we report a new approach to accelerate a common stack of spirals 3D image acquisition by pseudo golden-angle rotation and compressed sensing reconstruction without any degradation of time averaged blood flow images. 28 healthy volunteers were imaged at 3T with background-suppressed unbalanced pseudo-continuous ASL combined with a pseudo golden-angle Stack-of-Spirals 3D RARE readout. A fully-sampled perfusion-weighted volume was reconstructed by 3D non-uniform Fast Fourier Transform (nuFFT) followed by sum-of-squares combination of the 32 individual channels. Coil sensitivities were estimated followed by reconstruction of the 39 single-shot volumes using an L1-wavelet Compressed-Sensing reconstruction. Finally, brain connectivity analyses were performed in regions where BOLD signal suffers from low signal-to-noise ratio and susceptibility artifacts. Image quality, assessed with a non-reference 3D blurring metric, of full time averaged blood flow was comparable to a conventional interleaved acquisition. The temporal resolution provided by the acceleration enabled identification and quantification of resting-state networks even in inferior regions such as the amygdala and inferior frontal lobes, where susceptibility artifacts can degrade conventional resting-state fMRI acquisitions. This approach can provide measures of blood flow modulations and resting-state networks for free within any research or clinical protocol employing ASL for resting blood flow.
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影响因子：
3.3
作者：
Feng, Li;Grimm, Robert;Block, Kai Tobias;Chandarana, Hersh;Kim, Sungheon;Xu, Jian;Axel, Leon;Sodickson, Daniel K.;Otazo, Ricardo
通讯作者：
Otazo, Ricardo
影响因子：
3.3
作者：
Alsop, DC
通讯作者：
Alsop, DC
影响因子：
3.3
作者：
Cristobal-Huerta, A.;Poot, D. H. J.;Hernandez-Tamames, J. A.
通讯作者：
Hernandez-Tamames, J. A.
影响因子：
3.3
作者：
Feinberg, David A.;Beckett, Alexander;Chen, Liyong
通讯作者：
Chen, Liyong
影响因子：
3.3
作者：
Bastkowski, Rene;Weiss, Kilian;Giese, Daniel
通讯作者：
Giese, Daniel