Associations of a metal mixture with iron status in U.S. adolescents: Evidence from the National Health and Nutrition Examination Survey.
Associations of a metal mixture with iron status in U.S. adolescents: Evidence from the National Health and Nutrition Examination Survey.
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DOI：
10.1002/cad.20457
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发表时间：
2022-03
影响因子：
2.8
通讯作者：
Henn, Birgit Claus
中科院分区：
文献类型：
--
作者：
Schildroth, Samantha;Friedman, Alexa;Bauer, Julia Anglen;Henn, Birgit Claus
铁是青春期正常发育所必需的。暴露于个别环境金属（例如，铅）与青春期铁状态的改变有关，但对多种金属与铁状态的累积关系知之甚少。我们使用2017-2018年国家健康和营养检查调查（NHANES）的数据，研究了588名美国青少年（12-17岁）的金属混合物（铅，锰，镉，硒）与铁状态之间的关系。我们使用贝叶斯核机器回归（BKMR）估计了金属混合物与五个铁状态指标的累积和交互关联。较高浓度的锰和镉与较低的对数转换铁蛋白浓度。锰，镉和铅之间的相互作用，观察铁蛋白和转铁蛋白受体，铁的状态往往是更糟的所有金属的浓度较高。这些结果可能反映了环境金属和铁之间的竞争细胞摄取。混合金属暴露可能会改变正常的铁功能，这对青少年发育有影响。
Iron is needed for normal development in adolescence. Exposure to individual environmental metals (e.g., lead) has been associated with altered iron status in adolescence, but little is known about the cumulative associations of multiple metals with Fe status. We used data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) to examine associations between a metal mixture (lead, manganese, cadmium, selenium) and iron status in 588 U.S. adolescents (12–17 years). We estimated cumulative and interactive associations of the metal mixture with five iron status metrics using Bayesian Kernel Machine Regression (BKMR). Higher concentrations of manganese and cadmium were associated with lower log-transformed ferritin concentrations. Interactions were observed between manganese, cadmium, and lead for ferritin and the transferrin receptor, where iron status tended to be worse at higher concentrations of all metals. These results may reflect competition between environmental metals and iron for cellular uptake. Mixed metal exposures may alter normal iron function, which has implications for adolescent development.
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影响因子：
5.2
作者：
Choi, JW;Kim, SK
通讯作者：
Kim, SK
DOI：
10.1016/j.ijheh.2019.01.007
发表时间：
2019-04-01
影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
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作者：
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通讯作者：
LINEBERGER, TH
影响因子：
10.4
作者：
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通讯作者：
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