The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis.
The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis.
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血管生成素作为疾病血清生物标志物的潜力：系统评价和荟萃分析
DOI：
10.1155/2018/1984718
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Xu Z
中科院分区：
文献类型：
--
作者：
Yu D;Cai Y;Zhou W;Sheng J;Xu Z
背景血管生成素(Angigenin，Ang)是一种多功能的血管生成蛋白，参与正常发育和疾病的发生。血清血管紧张素转换酶水平异常在各种疾病中均有报道。然而，血管紧张素转换酶是否可以作为不同疾病的诊断或预后标记物仍然存在争议。方法在这里，我们利用PubMed、Web of Science和Scope搜索引擎对文献进行系统回顾和荟萃分析，以确定所有比较不同疾病患者和健康对照组之间血浆或血清Ang水平的文献，以及评估健康人群、孕妇或其他人口人群循环Ang水平的研究。结果健康人群血清血管紧张素转换酶浓度为336.14 ± 142.83 ng/ml，在不同人群和地区保持相对稳定。我们注意到，除了患有癌症或心血管疾病的患者外，患者和健康对照组之间的血清Ang水平没有显著差异。发生结直肠癌、急性髓系白血病、多发性骨髓瘤、骨髓增生异常综合征和心力衰竭的患者血清Ang浓度显著高于健康对照组。结论血管紧张素转换酶有可能成为肿瘤和心血管疾病的血清标志物。
Background Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate. Methods Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations. Results This study demonstrated that the serum ANG concentration in healthy populations was 336.14 ± 142.83 ng/ml and remained relatively stable in different populations and regions. We noted no significant differences in serum ANG levels between patients and healthy controls, except in cases in which patients suffered from cancer or cardiovascular diseases. The serum ANG concentrations were significantly higher in patients who developed colorectal cancer, acute myeloid leukemia, multiple myeloma, myelodysplastic syndromes, and heart failure than those in healthy controls. Conclusion ANG has the potential of being a serum biomarker for cancers and cardiovascular diseases.
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影响因子：
8.2
作者：
Aronis, K. N.;Diakopoulos, K. N.;Fiorenza, C. G.;Chamberland, J. P.;Mantzoros, C. S.
通讯作者：
Mantzoros, C. S.
DOI：
10.12659/msm.889752
发表时间：
2013-12-20
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Gkotzamanidou M;Christoulas D;Souliotis VL;Papatheodorou A;Dimopoulos MA;Terpos E
通讯作者：
Terpos E
影响因子：
6.6
作者：
Eissa, Sanaa;Swellam, Menha;El Ahmady, Omar
通讯作者：
El Ahmady, Omar
影响因子：
6.6
作者：
Chao, Yee;Wu, Chen-Yi;Li, Chung-Pin
通讯作者：
Li, Chung-Pin
影响因子：
2.9
作者：
FETT, JW;STRYDOM, DJ;VALLEE, BL
通讯作者：
VALLEE, BL