Immunity traits in pigs: substantial genetic variation and limited covariation.
Immunity traits in pigs: substantial genetic variation and limited covariation.
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DOI：
10.1371/journal.pone.0022717
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Rogel-Gaillard C
中科院分区：
文献类型：
--
作者：
Flori L;Gao Y;Laloë D;Lemonnier G;Leplat JJ;Teillaud A;Cossalter AM;Laffitte J;Pinton P;de Vaureix C;Bouffaud M;Mercat MJ;Lefèvre F;Oswald IP;Bidanel JP;Rogel-Gaillard C
通过提高对病原体的抗性来增加鲁棒性是家畜育种中的主要选择目标。由于抗性性状很难或不可能直接测量，潜在的间接标准是免疫性状（IT）的测量。我们的基本假设是，不关注特定病原体的IT水平定义了个体的免疫能力，从而预测了对病原体的反应。由于IT的变化取决于遗传、环境和可能的表观遗传因素，我们的目的是估计遗传学的相对重要性。在这份报告中，我们提出了一个大的遗传调查先天性和适应性IT在猪的家庭在同一环境中繁殖。对443头大白色猪进行猪支原体免疫试验，共检测了54个感染部位，并采用主成分分析和遗传参数估计相结合的方法进行了分析。IT包括特异性和非特异性抗体、血清炎症蛋白、通过血象和流式细胞术测定的细胞亚群、细胞因子（IFNα、TNFα、IL 6、IL 8、IL 12、IFNγ、IL 2、IL 4、IL 10）的离体产生、吞噬作用和淋巴细胞增殖。虽然6个IT的遗传力较弱或与零无显著差异，但分别有18个和30个IT具有中等（0.1<h2≤0.4）或高（h2>0.4）遗传力值。除了少数主要包括细胞亚群的性状外，IT之间的表型和遗传相关性很弱。PCA显示没有先天或适应性IT的集群。我们的研究结果表明，在许多先天和适应性IT的变化是遗传控制的猪，已经报告了少数性状的其他实验室。还观察到性状的有限冗余，证实了先天性和适应性IT之间的高度互补性。我们的数据提供了一个遗传框架，选择IT的选择标准包括在多性状选择方案，旨在提高生产和健康性状。
Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment. Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNα, TNFα, IL6, IL8, IL12, IFNγ, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1<h2≤0.4) or high (h2>0.4) heritability values, respectively. Phenotypic and genetic correlations between ITs were weak except for a few traits that mostly include cell subsets. PCA revealed no cluster of innate or adaptive ITs. Our results demonstrate that variation in many innate and adaptive ITs is genetically controlled in swine, as already reported for a smaller number of traits by other laboratories. A limited redundancy of the traits was also observed confirming the high degree of complementarity between innate and adaptive ITs. Our data provide a genetic framework for choosing ITs to be included as selection criteria in multitrait selection programmes that aim to improve both production and health traits.
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影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
5.1
作者：
Karin, Meyer
通讯作者：
Karin, Meyer
影响因子：
4.2
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
影响因子：
1.8
作者：
DEARCE, HD;ARTURSSON, K;ALM, GV
通讯作者：
ALM, GV
影响因子：
1.8
作者：
der Laan, MHP
通讯作者：
der Laan, MHP