Fatigue sensation induced by the sounds associated with mental fatigue and its related neural activities: revealed by magnetoencephalography.
Fatigue sensation induced by the sounds associated with mental fatigue and its related neural activities: revealed by magnetoencephalography.
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DOI：
10.1186/1744-9081-9-24
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发表时间：
2013-06-13
期刊：
影响因子：
--
通讯作者：
Watanabe Y
中科院分区：
文献类型：
--
作者：
Ishii A;Tanaka M;Iwamae M;Kim C;Yamano E;Watanabe Y
有人提出，不适当的条件疲劳感觉可能是慢性疲劳的一个原因。尽管在大鼠中有关于疲劳感觉的经典条件反射的报道，但在人类中还没有报道。我们的目的是检查精神疲劳感觉的经典条件反射是否可以发生在人类身上，并利用脑磁图（MEG）阐明疲劳感觉的神经机制。10名和9名健康志愿者分别参加了条件反射实验和对照实验。在条件反射实验中，我们使用节拍器声音作为条件刺激，双背任务试验作为非条件刺激来引起疲劳感觉。参与者在听节拍器声音6分钟的同时进行脑磁图测量。之后，进行了60分钟的疲劳诱导智力任务试验（双背任务试验），这是一种要求工作记忆的任务试验；在任务试验（条件作用）开始30分钟后开始使用节拍器声音。第二天，在听节拍器6分钟时测量神经活动。疲劳感觉水平也用视觉模拟量表进行评估。在对照实验中，参与者在第一天和第二天听节拍器，但他们不进行条件反射。对照实验不记录脑磁图。仅当参与者在第一天进行条件训练时，第二天听节拍器引起的疲劳感水平明显高于第一天。在条件反射后，8名参与者中有6名观察到岛叶皮层的等效电流偶极子（ECDs），平均潜伏期约为190毫秒，尽管在条件反射前没有发现任何参与者存在等效电流偶极子。我们证明节拍器的声音可以引起精神疲劳，因为声音与精神疲劳的反复配对，并且岛叶皮层参与了这种现象的神经基质。
It has been proposed that an inappropriately conditioned fatigue sensation could be one cause of chronic fatigue. Although classical conditioning of the fatigue sensation has been reported in rats, there have been no reports in humans. Our aim was to examine whether classical conditioning of the mental fatigue sensation can take place in humans and to clarify the neural mechanisms of fatigue sensation using magnetoencephalography (MEG). Ten and 9 healthy volunteers participated in a conditioning and a control experiment, respectively. In the conditioning experiment, we used metronome sounds as conditioned stimuli and two-back task trials as unconditioned stimuli to cause fatigue sensation. Participants underwent MEG measurement while listening to the metronome sounds for 6 min. Thereafter, fatigue-inducing mental task trials (two-back task trials), which are demanding working-memory task trials, were performed for 60 min; metronome sounds were started 30 min after the start of the task trials (conditioning session). The next day, neural activities while listening to the metronome for 6 min were measured. Levels of fatigue sensation were also assessed using a visual analogue scale. In the control experiment, participants listened to the metronome on the first and second days, but they did not perform conditioning session. MEG was not recorded in the control experiment. The level of fatigue sensation caused by listening to the metronome on the second day was significantly higher relative to that on the first day only when participants performed the conditioning session on the first day. Equivalent current dipoles (ECDs) in the insular cortex, with mean latencies of approximately 190 ms, were observed in six of eight participants after the conditioning session, although ECDs were not identified in any participant before the conditioning session. We demonstrated that the metronome sounds can cause mental fatigue sensation as a result of repeated pairings of the sounds with mental fatigue and that the insular cortex is involved in the neural substrates of this phenomenon.
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影响因子：
--
作者：
POMERANZ, B;MACAULAY, RJB;BENSON, H
通讯作者：
BENSON, H
影响因子：
56.9
作者：
AKSELROD, S;GORDON, D;COHEN, RJ
通讯作者：
COHEN, RJ
DOI：
10.1016/0735-1097(89)90408-7
发表时间：
1989-11-01
影响因子：
24
作者：
APPEL, ML;BERGER, RD;COHEN, RJ
通讯作者：
COHEN, RJ
DOI：
10.1016/s1090-3801(02)00043-5
发表时间：
2002-01-01
期刊：
EUROPEAN JOURNAL OF PAIN-LONDON
影响因子：
--
作者：
Flor, H;Birbaumer, N;Mucha, RF
通讯作者：
Mucha, RF
DOI：
10.1016/s1090-3801(99)90013-7
发表时间：
1999-01-01
期刊：
EUROPEAN JOURNAL OF PAIN-LONDON
影响因子：
--
作者：
Flor, H;Grüsser, SM
通讯作者：
Grüsser, SM