Is abnormal eutopic endometrium the cause of endometriosis? The role of eutopic endometrium in pathogenesis of endometriosis.
Is abnormal eutopic endometrium the cause of endometriosis? The role of eutopic endometrium in pathogenesis of endometriosis.
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DOI：
10.12659/msm.881707
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Lang JH
中科院分区：
文献类型：
--
作者：
Liu H;Lang JH
子宫内膜异位症（Endometriosis，EM）是严重影响育龄妇女健康和生殖功能的常见疾病之一。与正常子宫内膜相比，子宫内膜异位症患者的在位子宫内膜发生了根本性的异常变化。在位内膜增殖、着床和血管生成能力增强，更有可能逃避异位环境的不利条件。因此，在位子宫内膜的性质决定了回流子宫内膜组织的命运-生存或死亡。EM患者的异常子宫内膜组织回流至盆腔，完成3步发病过程（附着-侵袭-血管生成），最终发展为EM。异位子宫内膜也可能在子宫内膜异位症相关不孕中起重要作用。对子宫内膜异位症发病机制的认识最终将有助于发现新的诊断和治疗方法。子宫内膜标志物作为该病的微创诊断和直接治疗的原发部位在位子宫内膜有待进一步研究。
Endometriosis (EM) is one of the most common diseases which severely affect the health and reproductive function of women of childbearing age. There are fundamental abnormal changes within the eutopic endometrium of women with endometriosis compared to normal endometrium of women without endometriosis. Eutopic endometrium shows enhanced ability of proliferation, implantation and angiogenesis, and greater probability of escaping the unfavorable conditions of the ectopic environment. Therefore, the character of eutopic endometrium determines the fate of the backward-flowing endometrial tissue – to live or to die. The abnormal endometrial tissue in EM patients flows backward to the pelvic cavity, completing a 3-step procedure of pathogenesis (attachment-aggression-angiogenesis), and ultimately develops into EM. Abnormal eutopic endometrium may also play important roles in endometriosis-associated infertility. This recognition regarding the pathogenesis of endometriosis ultimately will help to discover new methods for diagnosis and treatment. Endometrial markers for micro-invasive diagnosis and direct treatment of eutopic endometrium as the origin of the disease should be further investigated.
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