Differentiation of prostate cancer cells using flexible fluorescent polymers.
Differentiation of prostate cancer cells using flexible fluorescent polymers.
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DOI:
10.1021/ac202301k
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发表时间:
2012-01-03
影响因子:
7.4
通讯作者:
Mallik, Sanku
中科院分区:
文献类型:
--
作者:
Scott, Michael D.;Dutta, Rinku;Haldar, Manas K.;Guo, Bin;Friesner, Daniel L.;Mallik, Sanku
Using water soluble, fluorescent, flexible polymers, we have devised a novel methodology for identification and differentiation of prostate cancer cells. By using a step-wise linear discriminant analysis we demonstrate that the differential modulations of the polymer emission intensities in the presence of conditioned cell culture media can be used to distinguish between prostate cancer subtypes and between cancerous and non-cancer cells. The differences in the compositions of the conditioned cell culture media are likely contributing to different fluorescence spectral patterns of the polymers. This in vitro approach may provide a novel platform for the development of an alternative prostate cancer diagnostic and subtyping technique.
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影响因子:
2.7
作者:
Dutta, Rinku;Scott, Michael D.;Haldar, Manas K.;Ganguly, Bratati;Srivastava, D. K.;Friesner, Daniel L.;Mallik, Sanku
通讯作者:
Mallik, Sanku
影响因子:
--
作者:
Koskensalo, Selja;Mrena, Johanna;Haglund, Caj
通讯作者:
Haglund, Caj
影响因子:
15
作者:
Bajaj, Avinash;Miranda, Oscar R.;Phillips, Ronnie;Kim, Ik-Bum;Jerry, D. Joseph;Bunz, Uwe H. F.;Rotello, Vincent M.
通讯作者:
Rotello, Vincent M.
影响因子:
8
作者:
Mazor, M;Kawano, Y;Kypta, RM
通讯作者:
Kypta, RM
DOI:
10.1107/s090744499900726x
发表时间:
1999-08-01
期刊:
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子:
--
作者:
Samanta, U;Pal, D;Chakrabarti, P
通讯作者:
Chakrabarti, P