Causal associations between changes in lipid profiles and risk of gallstone disease: a two-sample Mendelian randomization study.
Causal associations between changes in lipid profiles and risk of gallstone disease: a two-sample Mendelian randomization study.
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血脂变化与胆结石疾病风险之间的因果关系：两样本孟德尔随机化研究
DOI：
10.21037/atm-21-4007
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发表时间：
2022-08
影响因子：
--
通讯作者：
Zheng, Jun
中科院分区：
文献类型：
--
作者：
Yuan, Xiaofeng;Chen, Haitian;Zeng, Kaining;Xiao, Jiaqi;Liu, Jiaqing;Lin, Guowang;Zhang, Jiebin;Lu, Tongyu;Cai, Jianye;Yao, Jia;Zhang, Yingcai;Sui, Xin;Liang, Jinliang;Zheng, Jun
关键词：
观察性研究显示，非酒精性脂肪肝 (NAFLD) 与胆石病 (GSD) 有关；然而，某些血脂谱与 GSD 之间的关系仍不清楚。我们采用了两个样本孟德尔随机化 (MR) 框架，通过应用不同的统计方法来评估血脂谱和 GSD 之间的因果关系。我们从之前的全基因组关联研究 (GWAS) 中鉴定出了血脂和 NAFLD 的单核苷酸多态性 (SNP)。我们检索了 10,520 个病例和 361,194 个对照的 GSD SNP，并使用英国生物银行的 GWAS 摘要数据验证了我们的估计。我们还进行了性别分层分析。根据对低密度脂蛋白胆固醇 (LDLC)、高密度脂蛋白胆固醇 (HDLC)、甘油三酯 (TG) 和 NAFLD 分别 41、59、35 和 2 个 SNP 的汇总估计，我们没有发现遗传预测血脂谱与 GSD 之间存在因果关系的证据。每 0.98 mmol/L，LDLC 的比值比为 0.995 [95% 置信区间 (CI)：0.994–0.998]；每 0.41 mmol/L，HDLC 的比值比为 0.999（95% CI：0.996–1.003）；TG 的比值比为 0.997（95% CI：0.994–1.001）每 1 毫摩尔/升，以及 NAFLD 为 0.993（95% CI：0.984–1.003）。在验证 MR 分析或性别分层分析中，没有发现血脂谱与 GSD 之间存在关联的证据。基因预测的高脂血症或 NAFLD 与 GSD 没有因果关系。
Nonalcoholic fatty liver disease (NAFLD) has been linked to gallstone disease (GSD) in observational studies; however, the relationships between certain lipid profiles and GSD remain unclear. We adopted a two-sample Mendelian randomization (MR) framework by applying different statistical methods to assess causalities between lipid profiles and GSD. We identified single-nucleotide polymorphisms (SNPs) for blood lipids and NAFLD from separate previous genome-wide association studies (GWASs). We retrieved GSD SNPs attributed to 10,520 cases and 361,194 controls and validated our estimates using GWAS summary data from UK Biobank. We also performed sex-stratified analyses. Based on the summary estimates of 41, 59, 35, and 2 SNPs for low-density lipoprotein cholesterol (LDLC), high-density lipoprotein cholesterol (HDLC), triglycerides (TGs), and NAFLD, respectively, we found no evidence of a causal relationship between genetically-predicted lipid profiles and GSD. The odds ratios were 0.995 for LDLC [95% confidence interval (CI): 0.994–0.998] per 0.98 mmol/L, 0.999 for HDLC (95% CI: 0.996–1.003) per 0.41 mmol/L, 0.997 for TGs (95% CI: 0.994–1.001) per 1 mmol/L, and 0.993 for NAFLD (95% CI: 0.984–1.003). No evidence of associations between lipid profile s and GSD in validation MR analyses or the sex-stratification analyses was noted. Genetically predicted hyperlipidemia or NAFLD is not causally associated with GSD.
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全基因组关联荟萃分析产生了20个与胆结石疾病相关的基因座。
影响因子：
16.6
作者：
Ferkingstad E;Oddsson A;Gretarsdottir S;Benonisdottir S;Thorleifsson G;Deaton AM;Jonsson S;Stefansson OA;Norddahl GL;Zink F;Arnadottir GA;Gunnarsson B;Halldorsson GH;Helgadottir A;Jensson BO;Kristjansson RP;Sveinbjornsson G;Sverrisson DA;Masson G;Olafsson I;Eyjolfsson GI;Sigurdardottir O;Holm H;Jonsdottir I;Olafsson S;Steingrimsdottir T;Rafnar T;Bjornsson ES;Thorsteinsdottir U;Gudbjartsson DF;Sulem P;Stefansson K
通讯作者：
Stefansson K
影响因子：
3.9
作者：
Chang Y;Noh YH;Suh BS;Kim Y;Sung E;Jung HS;Kim CW;Kwon MJ;Yun KE;Noh JW;Shin H;Cho YK;Ryu S
通讯作者：
Ryu S
影响因子：
1.9
作者：
Koller, Tomas;Kollerova, Jana;Payer, Juraj
通讯作者：
Payer, Juraj
DOI：
10.1097/meg.0b013e32832fcdf0
发表时间：
2010-01-01
影响因子：
2.1
作者：
Caballeria, Llorenc;Pera, Guillem;Maite Aizpurua, Miren
通讯作者：
Maite Aizpurua, Miren
影响因子：
6.4
作者：
Andreotti, Gabriella;Chen, Jinbo;Hsing, Ann W.
通讯作者：
Hsing, Ann W.