Dietary isoflavone and the risk of colorectal adenoma: a case-control study in Japan.
Dietary isoflavone and the risk of colorectal adenoma: a case-control study in Japan.
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膳食异黄酮与结直肠腺瘤的风险：日本的一项病例对照研究。
DOI：
10.1038/sj.bjc.6605088
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发表时间：
2009-06-02
影响因子：
8.8
通讯作者：
Tsugane, S.
中科院分区：
文献类型：
--
作者：
Akhter, M.;Iwasaki, M.;Yamaji, T.;Sasazuki, S.;Tsugane, S.
我们在日本人群中进行了一项病例对照研究，以调查饮食中异黄酮类摄入量与结直肠腺瘤风险之间的关系。作为癌症筛查计划的一部分，参与者接受了放大结肠镜检查，并将染料扩散作为癌症筛查计划的一部分，在进行结肠镜检查之前，参与者回答了一份自我填写的问卷，其中包括生活方式信息和145种食物的摄入量。共入选病例组721例，对照组697例。用非条件Logistic回归模型估计优势比(OR)和95%可信区间(CI)。我们发现，在男性和女性中，饮食中的异黄酮类摄入量与结直肠腺瘤风险之间存在显著的负相关。然而，反向关联并不是线性的；相反，第一个四分位数以上的所有四分位数都显示出类似的风险降低，多变量调整后的OR值和95%的顺应性与第二、三和最高四分位数的最低四分位数分别为0.77(0.57-1.04)、0.76(0.56-1.02)和0.70(0.51-0.96)相比(趋势P=0.03)。有趣的是，观察到的这种关联在女性中比在男性中更明显。观察到的天花板效应与较高的异黄酮类摄入量相关，表明饮食中较低的异黄酮类摄入量可能与日本人群中结直肠腺瘤风险的增加有关。
We conducted a case–control study in a Japanese population to investigate the association between dietary isoflavone intake and the risk of colorectal adenoma. Participants who underwent magnifying colonoscopy with dye spreading as part of a cancer screening programme responded to a self-administered questionnaire, which included lifestyle information and intake of 145 food items, before the colonoscopy. A total of 721 case and 697 control subjects were enrolled. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models. We found a significant inverse association between dietary isoflavone intake and the risk of colorectal adenoma in men and women combined. However, the inverse association was not linear; rather, all quartiles above the first showed a similar decrease in risk, with multivariable-adjusted ORs and 95% CIs compared with the lowest quartile of 0.77 (0.57–1.04), 0.76 (0.56–1.02) and 0.70 (0.51–0.96) in the second, third and highest quartiles, respectively (P for trend=0.03). Of interest, the observed association was more prominent in women than in men. The observed ceiling effect associated with higher isoflavone intake suggests that a lower intake of dietary isoflavone might be associated with an increased risk of colorectal adenoma in Japanese populations.
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影响因子：
3.8
作者：
Akhter, Munira;Inoue, Manami;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
158.5
作者：
Chlebowski, RT;Wactawski-Wende, J;Carleton, R
通讯作者：
Carleton, R
影响因子：
2.3
作者：
Otani, Tetsuya;Iwasaki, Motoki;Tsugane, Shoichiro
通讯作者：
Tsugane, Shoichiro
影响因子：
4.2
作者：
Yamamoto, S;Sobue, T;Tsugane, S
通讯作者：
Tsugane, S
影响因子：
2.2
作者：
HOSHIYAMA, Y;SEKINE, T;SASABA, T
通讯作者：
SASABA, T